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News | Article | Photosynthesis
A team from the I2BC has just demonstrated, using transient absorption spectroscopy, that the repair of UV-induced damage in DNA by a repair enzyme (6-4) photolyase occurs in two successive photoreactions, corroborating and detailing the two-photon reaction model at work in the core of these enzymes.
Flavoenzymes photolyases are natural catalysts present in all kingdoms of life. They use sunlight to reverse carcinogenic chemical modifications of DNA caused by UV-light. Scientists from the 3P (Photobiology, Photosynthesis, Photocatalysis) team of the I2BC have been exploring the molecular mechanisms by which these essential photoenzymes repair DNA since 1999. To learn more, read the news recently published on the I2BC website : News-2022 – Institute for Integrative Biology of the Cell (paris-saclay.fr) Contact : Pavel Muller firstname.lastname@example.org
Klaus Brettel, Pavel Müller, Junpei Yamamoto. Kinetics of Electron Returns in Successive Two-Photon DNA Repair by (6-4) Photolyase. ACS Catal. 2022, 12, 3041–3045 https://doi.org/10.1021/acscatal.2c00492
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.