To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Team LeadersVincent Divevincent.email@example.com
CEA has a long-term tradition in radioactivity manipulation that is maintained and developed in SIMOPRO for the labelling of peptides, pseudopeptides and proteins with tritium, but also with 14C and recently with 99mTc.
This activity gives rise to multiple collaborations including both with academic and industrial partners.
Labelled of biomolecules with stable isotopes such 3H and 14C are useful to establish in preliminary experiments either pharmacokinetics and tissue biodistribution of potential therapeutic molecule. The latter objective can be assessed by using digital radioimagers, like those developed by the Biospace company, the beta-imager.
The beta-imager allows real-time imaging, with extreme counting sensitivity (0.007 cmp/mm2 for 3H and 0.01 cmp/mm2 for 14C) and absolute signal quantification.
Peptides and proteins are labelled with near-infrared fluorescent group allowing their detection in vivo by 3D-fluorescent imaging system (FMT-2500 from Perkin Elmer).
Performed in a dedicated animal facility, the most common experiments in SIMOPRO are:
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.