The team's work focuses on the development of therapeutic molecules from research on bacterial and plant toxins.
Team Leader
Daniel Gillet
daniel.gillet@cea.fr
The team is working on :
- Antidotes against ricin, Shigatoxins and a wide array of intracellular pathogens
- Molecules enhancing therapeutic oligonucleotide delivery
- Immuno-stimulating molecules boosting innate and adaptive immunity
- Inhibitor of HB-EGF derived from diphtheria toxin, for the treatment of rapidly progressive glomerulonephritis
Ricin, Shigatoxin, Diphteria toxin
Retro-1 , Retro-2.1, Intracellular action of Retro-2.1
Retro-1 and Retro-2.1 are molecules blocking the intracellular trafficking of ricin and Shigatoxins in cells.
Our group is strongly involved in the joint ministerial program of R&D against CBRNE threats launched by the General Secretary for National Defense and Security and conducted by CEA under the joint supervision of CEA and the Armaments Procurement Agency (DGA).