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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Une collaboration dirigée par le LERI (SPI/DMTS) a mis au point un dispositif de microfluidique en gouttes pour tester rapidement et efficacement la susceptibilité à la colistine, un antibiotique pour lequel des phénomènes de résistance bactérienne ont été observés. L’Intelligence artificielle complète la méthode pour faciliter l’étape d’analyse des images et augmenter la sensibilité du test.
A study conducted by NeuroSpin researchers reveals abnormalities in functional brain connectivity in the sub-nucleus region of the amygdala (emotion center), in patients with bipolar disorder. These anomalies, which depend on whether the patient is depressed or manic, are potential biomarkers of interest.
Des résultats obtenus par une équipe du SPI, en collaboration avec CERES Brain Therapeutics et l’Université de Sharjah (Emirats arabes unis), indique que le niveau de méthylation de l’ADN pourrait constituer un biomarqueur intéressant de l’efficacité thérapeutique d’un traitement potentiel du déficit en transporteur de la créatine lié à l’X.
A BioMaps team has used PET imaging to monitor glucose metabolism as a marker of the cerebral impact of smoking cessation, as well as the effects of a promising drug-candidate for the treatment of such cessation. By revealing the restoration of normal activity in the brain area associated with craving, these results offer hope for smoking cessation in humans
An I2BC team has revealed the structure of the C-terminal transmembrane region of the SARS-CoV-2 protein nsp3, essential for virus replication. This region self-assembles into hexamers that form molecular pores on the surface of double-membrane vesicles, the sites of viral genome replication. Nsp3 therefore appears to be a promising therapeutic target.
A NeuroSpin team analyzed the MEG response of volunteers exposed to auditory sequences organized in network. Finding that participants' brain activity was sensitive to the structure of the network, it concluded that learning the structure of auditory sequences involves a single cognitive process, associative learning.
Une équipe du SCBM met au point une méthode d’échange isotopique du soufre pour le marquage de molécules biologiquement actives. Telle une plateforme isotopique multi-échangeable, le procédé permet également un échange isotopique du carbone et d’hydrogène donnant accès à un grand nombre d’isotopologues. L’équipe met en avant le potentiel de la méthode pour vérifier l’authenticité de molécules organiques commerciales.
A collaborative study led by NeuroSpin researchers analyzed anatomical MRI images of 662 young subjects from the Healthy Brain Network cohort, to map different features of cognitive function linked to cerebellar structure. It shows that there is a complex association between key cognitive functions and particular lobules of the cerebellum.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.