To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Institute | Structural biology
The Institute for Integrative Biology of the Cell (I2BC) UMR 9198 is a “Unité Mixte de Recherche” (joint research unit ; UMR ) supported by both Université Paris-Sud, the CNRS and the CEA. The Institute regroup 80 teams of scientists, 15 technological facilities from 8 research units (CGM, IBBMC, IGM, ISV, LEBS, VMS, SB2SM, SBiGeM)The Institute is in 3 research campus (Orsay Campus of the Université Paris Sud, Gif Sur Yvette Campus of CNRS, and Saclay Campus of CEA) with 14 buildings. All the I2BC activities will be join on the Gif Sur Yvette Campus in 2018.
Adress: Avenue de la Terrasse, Bâtiment 21,91190 Gif-sur-Yvette Cedex
I2BC@Saclay Department of the Frédéric Joliot Institute for Life Sciences permanently receives and prepares approximately 120 doctoral students., directed by Thierry Meinnel, carries out research in
Integrative Biology of the Cell around four thematic axes :
I2BC researchers identify drought-resistant mutants of the model plant A. thaliana. These mutants are no longer able to carry out the state transition, a process that enables plants to adjust the absorption of light by their two photosystems in an optimal way. They could constitute a way of improving crop resistance to drought.
In an article published in the journal Nucleic Acids Research, scientists from the I2BC, lPBS and the Institute for Structural and Chemical Biology (University of Leicester, UK) demonstrate how phytic acid, a product of cellular metabolism, stabilises the assembly of a complex enabling the repair of DNA breaks in humans.
Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health.
En substituant des segments d’hélice alpha par des segments d’oligo-urées dans un peptide inhibiteur d’ASF1, lui conférant ainsi une résistance accrue aux protéases, des chercheurs de l’I2BC en collaboration avec l’IECB explorent les modes de liaison de ces chimères peptide-urée à leur cible.
A team from I2BC has shown that the Mediator of transcription from the yeast S.cerevisiae physically interacts with the chromatin remodeling complex, and that by co-localizing with this complex on DNA promoter regions, it contributes to chromatin organization favorable to transcription initiation.
Des chercheurs de l’I2BC ont contribué à une étude menée par l’Iramis qui dévoile le rôle des protéines dans la dispersion des microplastiques dans l’eau. Leurs résultats permettent d’imaginer de nouvelles stratégies low tech pour débarrasser l’eau de cette pollution.
An international collaboration led by researchers from I2BC/CEA-Joliot and IPBS (Toulouse) has solved the atomic structure of molecular assemblies involved in the repair of DNA double-strand breaks. The diversity of assemblies involving the PAXX protein identified in this study highlights the great flexibility of the repair machinery, which could reflect its ability to adapt to biological conditions. The results were published in Science Advances.
Its Research Teams are all members of the
Institute of Integrative Biology of the Cell (I2BC), a Joint research unit (UMR 9198), whose tutors are CEA, CNRS and Paris Sud University. Currently located on the site of Saclay, they will join all the staff of the I2BC in 2019 in a new building, on the CNRS campus of Gif-sur-Yvette.
To carry out their activities, researchers of I2BC@Saclay Department have access to research platforms certified
IBiSA within the
Frédéric Joliot Institute for Life Sciences:
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.