To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Institute | Structural biology
The Institute for Integrative Biology of the Cell (I2BC) UMR 9198 is a “Unité Mixte de Recherche” (joint research unit ; UMR ) supported by both Université Paris-Sud, the CNRS and the CEA. The Institute regroup 80 teams of scientists, 15 technological facilities from 8 research units (CGM, IBBMC, IGM, ISV, LEBS, VMS, SB2SM, SBiGeM)The Institute is in 3 research campus (Orsay Campus of the Université Paris Sud, Gif Sur Yvette Campus of CNRS, and Saclay Campus of CEA) with 14 buildings. All the I2BC activities will be join on the Gif Sur Yvette Campus in 2018.
Adress: Avenue de la Terrasse, Bâtiment 21,91190 Gif-sur-Yvette Cedex
I2BC@Saclay Department of the Frédéric Joliot Institute for Life Sciences permanently receives and prepares approximately 120 doctoral students., directed by Thierry Meinnel, carries out research in
Integrative Biology of the Cell around four thematic axes :
Using molecular dynamics simulation and NMR studies, I2BC researchers detail the restriction mechanisms of BAF protein dynamics due to its phosphorylation.
The protocols applied for in vivo mapping of nuclear processes, at the genome scale and at very high spatial resolution, do not allow for high temporal resolution. A team from the I2BC has therefore demonstrated that such an understanding could be wrong by using a mathematical model. This model can be applied to any process that can be modeled by a transition between two states.
A team from SBIGeM (I2BC) shows, by several spectroscopic approaches, that the assembly of a Fe-S cluster, the catalytic center of many essential proteins, is a highly conserved process, initiated by the insertion of ferrous iron at the cysteine-rich assembly site of the scaffold protein ISCU (Iron-sulfur cluster assembly enzyme).
An I2BC team has analyzed, at the genome scale of the yeast S.cerevisiae, the functional interactions between the Mediator of gene transcription and DNA repair proteins, reinforcing the idea that these two fundamental cellular processes are closely linked.
Researchers from ICMMO* and ISMO**, in collaboration with a team from I2BC, show that the urea-decorated iron porphyrin catalysts they developed previously for the electro-catalysis of CO2, can be successfully employed in a photo-catalytic approach.
A collaborative study involving an I2BC team unveils the mechanism of autoinhibition of the human flippase ATP8B1, as well as its regulation by lipids and phosphorylation. The study provides a better understanding of the impact of flippase mutations responsible for intrahepatic cholestasis on its enzymatic activity.
A team from the I2BC has just demonstrated, using transient absorption spectroscopy, that the repair of UV-induced damage in DNA by a repair enzyme (6-4) photolyase occurs in two successive photoreactions.
Its Research Teams are all members of the
Institute of Integrative Biology of the Cell (I2BC), a Joint research unit (UMR 9198), whose tutors are CEA, CNRS and Paris Sud University. Currently located on the site of Saclay, they will join all the staff of the I2BC in 2019 in a new building, on the CNRS campus of Gif-sur-Yvette.
To carry out their activities, researchers of I2BC@Saclay Department have access to research platforms certified
IBiSA within the
Frédéric Joliot Institute for Life Sciences:
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.