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Integrative Biology and Molecular Genetics Unit




Published on 2 June 2020
The research projects of the Integrative Biology and Molecular Genetics Unit (SBIGeM) aim at understanding the fundamental mechanisms used by eukaryotic and prokaryotic cells to adapt to their natural environment or to a variety of stresses.   
Photo_JYT.jpgHead of Unit
Jean-Yves THURET
+33 1 69 08 64 25
Catherine DOREAU
+33 1 69 08 80 26
Monique BIZEUL
+33 1 69 08 78 45
Lab Manager
Emmanuel GABETTE
+33 1 69 08 40 85

This unit is part of the Institute of Integrative Biology of the Cell (I2BC), established on 1 January 2015 (mixed research unit (UMR) 9198, CEA/CNRS/Paris Sud University).

The teams of the Unit try to unravel the mechanisms that control DNA damage and cellular proliferation, those that regulate gene expression, the implication of chromatin structure in epigenetic mechanisms, and the nature of the stress responses induced by oxidants, heavy metals, nanoparticules or ionizing radiations.

Various biological model systems chosen for their biological and experimental relevance are studied (bacteria, yeast Saccharomyces cerevisae, the mouse or mammalian cell cultures). The research teams use a large number of experimental approaches that are either targeted (biochemistry, genetics, molecular and cellular biology…) or global (transcriptomics, proteomics, metabolomics, bio-informatics, model building…) to understand the mechanisms under study in an integrated fashion at the molecular, cellular or tissular level.

The Unit is organized in four laboratories:

Peptidic Biosynthesis and Gene expression Laboratory (Muriel GONDRY)
Mammalian Epigenomics Laboratory (Matthieu GERARD)
Oxidative Stress and Cancer Laboratory (Michel TOLEDANO)
Transcription and Genomics Laboratory (Julie SOUTOURINA)


SBIGeM​ publications


The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation
Arbona JM., Golder A., Hyrien O., Arneodo A. and Audit B.
A mating-type mutagenesis screen identifies a zinc-finger protein required for specific DNA excision events in Paramecium
Bhullar S., Denby Wilkes C., Arnaiz O., Nowacki M., Sperling L. and Meyer E.
Structural basis for partition of the cyclodipeptide synthases into two subfamilies
Bourgeois G., Seguin J., Babin M., Belin P., Moutiez M., Mechulam Y., Gondry M. and Schmitt E.
Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons
Calderari S., Ria M., Gerard C., Nogueira T. C., Villate O., Collins S. C., Neil H., Gervasi N., Hue C., Suarez-Zamorano N., Prado C., Cnop M., Bihoreau M. T., Kaisaki P. J., Cazier J. B., Julier C., Lathrop M., Werner M., Eizirik D. L. and Gauguier D.
Guidelines and recommendations on yeast cell death nomenclature
Carmona-Gutierrez D., Bauer M. A., Zimmermann A., Aguilera A., Austriaco N., Ayscough K., Balzan R., Bar-Nun S., Barrientos A., Belenky P., Blondel M., Braun R. J., Breitenbach M., Burhans W. C., Buttner S., Cavalieri D., Chang M., Cooper K. F., Corte-Real M., Costa V., Cullin C., Dawes I., Dengjel J., Dickman M. B., Eisenberg T., Fahrenkrog B., Fasel N., Frohlich K. U., Gargouri A., Giannattasio S., Goffrini P., Gourlay C. W., Grant C. M., Greenwood M. T., Guaragnella N., Heger T., Heinisch J., Herker E., Herrmann J. M., Hofer S., Jimenez-Ruiz A., Jungwirth H., Kainz K., Kontoyiannis D. P., Ludovico P., Manon S., Martegani E., Mazzoni C., Megeney L. A., Meisinger C., Nielsen J., Nystrom T., Osiewacz H. D., Outeiro T. F., Park H. O., Pendl T., Petranovic D., Picot S., Polcic P., Powers T., Ramsdale M., Rinnerthaler M., Rockenfeller P., Ruckenstuhl C., Schaffrath R., Segovia M., Severin F. F., Sharon A., Sigrist S. J., Sommer-Ruck C., Sousa M. J., Thevelein J. M., Thevissen K., Titorenko V., Toledano M. B., Tuite M., Vogtle F. N., Westermann B., Winderickx J., Wissing S., Wolfl S., Zhang Z. J., Zhao R. Y., Zhou B., Galluzzi L., Kroemer G. and Madeo F.
A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes
Gondry M., Jacques I. B., Thai R., Babin M., Canu N., Seguin J., Belin P., Pernodet J. L. and Moutiez M.
Importance of Post-translational Modifications in the Interaction of Proteins with Mineral Surfaces: The Case of Arginine Methylation and Silica surfaces
Marichal L., Renault J. P., Chedin S., Lagniel G., Klein G., Aude J. C., Tellier-Lebegue C., Armengaud J., Pin S., Labarre J. and Boulard Y.
Mechanistic View and Genetic Control of DNA Recombination during Meiosis
Marsolier-Kergoat M. C., Khan M. M., Schott J., Zhu X. and Llorente B.
Nrf2-activated expression of sulfiredoxin contributes to urethane-induced lung tumorigenesis
Mishra M., Jiang H., Chawsheen H. A., Gerard M., Toledano M. B. and Wei Q.
Parsing protein sulfinic acid switches
Rahuel-Clermont S. and Toledano M. B.
Time-course of thiol oxidation of protein phosphatases during cerulein-induced acute pancreatitis
Rius-Perez S., Perez S., Marti-Andres P., Finamor I., Talens-Visconti R., Cuadrado A., Toledano MB. and Sastre J.
Cyclization Reaction Catalyzed by Cyclodipeptide Synthases Relies on a Conserved Tyrosine Residue
Schmitt E., Bourgeois G., Gondry M. and Aleksandrov A.
Transcription regulation by the Mediator complex
Soutourina J.
Histone Variant H2AL2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells
Barral S., Morozumi Y., Tanaka H., Montellier E., Govin J., Dieuleveult M., Charbonnier G., Coute Y., Puthier D., Buchou T., Boussouar F., Urahama T., Fenaille F., Curtet S., Hery P., Fernandez-Nunez N., Shiota H., Gerard M., Rousseaux S., Kurumizaka H. and Khochbin S.
Efficient Depletion of Essential Gene Products for Loss-of-Function Studies in Embryonic Stem Cells
Berlivet S., Hmitou I., Picaud H. and Gerard M.
A scaffold protein that chaperones a cysteine-sulfenic acid in H2O2 signaling
Bersweiler A., D'Autreaux B., Mazon H., Kriznik A., Belli G., Delaunay-Moisan A., Toledano MB. and Rahuel-Clermont S.
Light-sensing via hydrogen peroxide and a peroxiredoxin
Bodvard K., Peeters K., Roger F., Romanov N., Igbaria A., Welkenhuysen N., Palais G., Reiter W., Toledano MB., Kall M. and Molin M.
Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
Contrepois K., Coudereau C., Benayoun BA., Schuler N., Roux PF., Bischof O., Courbeyrette R., Carvalho C., Thuret JY., Ma ZH., Derbois C., Nevers MC., Volland H., Redon CE., Bonner WM., Deleuze JF., Wiel C., Bernard D., Snyder MP., Rube CE., Olaso R., Fenaille F. and Mann C.
Reexamining the Function of Glutathione in Oxidative Protein Folding and Secretion
Delaunay-Moisan A., Ponsero A. and Toledano MB.
Toward understanding of the mechanisms of Mediator function in vivo: Focus on the preinitiation complex assembly
Eychenne T., Werner M. and Soutourina J.
Nonlinear feedback drives homeostatic plasticity in H2O2 stress response
Goulev Y., Morlot S., Matifas A., Huang B., Molin M., Toledano MB. and Charvin G.
A meiosis-specific Spt5 homolog involved in non-coding transcription
Gruchota J., Denby-Wilkes C., Arnaiz O., Sperling L. and Nowak JK.
Flow cytometry sorting of nuclei enables the first global characterization of Paramecium germline DNA and transposable elements
Guerin F., Arnaiz O., Boggetto N., Wilkes CD., Meyer E., Sperling L. and Duharcourt S.
The alternative sigma factor sigma(B) plays a crucial role in adaptive strategies of Clostridium difficile during gut infection
Kint N., Janoir C., Monot M., Hoys S., Soutourina O., Dupuy B. and Martin-Verstraete I.
Publisher Correction: Membrane association of the bacterial riboregulator Hfq and functional perspectives
Malabirade A., Morgado-Brajones J., Trepout S., Wien F., Marquez I., Seguin J., Marco S., Velez M. and Arluison V.
Membrane association of the bacterial riboregulator Hfq and functional perspectives
Malabirade A., Morgado-Brajones J., Trepout S., Wien F., Marquez I., Seguin J., Marco S., Velez M. and Arluison V.
Study of the protein corona formed by the adsorption of hemoproteins on silica nanoparticles
Marichal L., Renault JP., Cousin F., Combet S., Gatin A., Aude JC., Boulard Y., Labarre J. and Pin S.
Aminoacyl-tRNA-Utilizing Enzymes in Natural Product Biosynthesis
Moutiez M., Belin P. and Gondry M.
Cellular Durotaxis from Differentially Persistent Motility
Novikova EA., Raab M., Discher DE. and Storm C.
BIOPHYSICAL JOURNAL 112 (3), 436A-436A, 2017
Genome data on the extinct Bison schoetensacki establish it as a sister species of the extant European bison (Bison bonasus)
Palacio P., Berthonaud V., Guerin C., Lambourdiere J., Maksud F., Philippe M., Plaire D., Stafford T., Marsolier-Kergoat MC. and Elalouf JM.
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