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Laboratory | DNA | Stress response


LBPEG

Peptide Biosynthesis and Gene Expression Laboratory

FRENCH

Published on 25 January 2023
The Peptide Biosynthesis and Gene Expression Laboratory (PBGEL) now consists of two teams: the team Enzymology and Non-Ribosomal Peptide Biosynthesis and the team Nuclear Regulation and Stress.

Gondry.jpg

 

 

 

Team Leader

Muriel GONDRY
+33 1 69 08 76 47
Muriel.Gondry@Cea.Fr
Nuclear Regulation and Stress
(Joël ACKER - Christine CONESA)

Staff

Joël ACKER - Researcher - Pascal BELIN - Researcher - Laurent CONSENTINO - Post doctoral fellow
Christine CONESA - Researcher - Muriel GONDRY - Researcher - Mireille MOUTIEZ - Researcher
Carine TELLIER-LEBEGUE - Technician

 Content Editor

Publications HAL de Joël, ACKER ; Pascal, BELIN ; Christine, CONESA; Laurent, CONSENTINO; Muriel, GONDRY; Mireille, MOUTIEZ; de la structure I2BC

2023

Journal articles

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Phong Quoc Nguyen, Sonia Huecas, Amna Asif-Laidin, Adrián Plaza-Pegueroles, Beatrice Capuzzi, et al.. Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration. Nature Communications, 2023, 14 (1), pp.1729. ⟨10.1038/s41467-023-37109-4⟩. ⟨hal-04056067⟩
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https://hal.science/hal-04056067/file/s41467-023-37109-4.pdf BibTex

Conference papers

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Zahra Marouf, Paloma Fernandez Varela, Carine Tellier, Matthieu Glousieau, Nelly Morellet, et al.. Molecular bases of the specific recognition of tRNA by cyclodipeptide synthases: Use of RNA microhelices to mimick tRNA acceptor stem. Journée ED ITFA, ED ITFA, Jun 2023, Orsay, France. ⟨hal-04397018⟩
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Poster communications

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Zahra Marouf, Paloma Fernandez Varela, Carine Tellier, Matthieu Glousieau, Pierre Legrand, et al.. Molecular basis of the specific recognition of tRNA substrates by cyclodipeptide synthases explored using RNA microhelices. Congrès BSI, Nov 2023, Marseille, France. ⟨hal-04397161⟩
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2022

Journal articles

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Anastasia Barkova, Indranil Adhya, Christine Conesa, Amna Asif-Laidin, Amandine Bonnet, et al.. A proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition. Mobile DNA, 2022, 13, pp.26. ⟨10.1186/s13100-022-00284-0⟩. ⟨hal-04258718⟩
Accès au texte intégral et bibtex
https://hal.science/hal-04258718/file/Barkova%20et%20al%20Mobile%20DNA%202022.pdf BibTex

Conference papers

ref_biblio
Zahra Marouf, Paloma Fernandez Varela, Carine Tellier, Matthieu Glousieau, Nelly Morellet, et al.. Deciphering the interactions of Cyclodipeptide Synthases with their shortened tRNA substrates by NMR, X-ray crystallography and biophysical approaches. Journée BSI@Paris-Saclay, Réseau BSI@Paris-Saclay, Nov 2022, Gif-sur-Yvette, France. ⟨hal-04396986⟩
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Poster communications

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Zahra Marouf, Paloma Fernandez Varela, Carine Tellier, Matthieu Glousieau, Jérôme Séguin, et al.. Structural and functional studies of cyclodipeptide synthases with RNA microhelices mimicking their tRNA susbtrates.. 33ème édition de la Conférence Européenne de Cristallographie (ECM33), Aug 2022, Versailles, France. ⟨hal-04397149⟩
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2021

Journal articles

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Phong Quoc Nguyen, Christine Conesa, Elise Rabut, Gabriel Bragagnolo, Célia Gouzerh, et al.. Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity $in\ vitro$. Journal of Biological Chemistry, 2021, 297 (4), pp.101093. ⟨10.1016/j.jbc.2021.101093⟩. ⟨hal-03402697⟩
Accès au texte intégral et bibtex
https://amu.hal.science/hal-03402697/file/pho1.pdf BibTex
ref_biblio
Anastasia Croitoru, Morgan Babin, Hannu Myllykallio, Muriel Gondry, Alexey Aleksandrov. Cyclodipeptide synthases of the NYH subfamily recognize tRNA using an α-helix enriched with positive residues. Biochemistry, 2021, 60 (1), pp.64-76. ⟨10.1021/acs.biochem.0c00761⟩. ⟨hal-03084339⟩
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https://hal.science/hal-03084339/file/Aleksandrov2020%20Biochemistry.pdf BibTex

Poster communications

ref_biblio
Zahra Marouf, Nelly Morellet, Carine Tellier, Matthieu Glousieau, Eric Jacquet, et al.. Structural studies of cyclodipeptide synthases with RNA microhelices mimicking their natural tRNA susbtrates. congrès BSI, Nov 2021, Gif-sur-Yvette, France. ⟨hal-04397035⟩
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2020

Journal articles

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Amna Asif-Laidin, Christine Conesa, Amandine Bonnet, Camille Grison, Indranil Adhya, et al.. A small targeting domain in Ty1 integrase is sufficient to direct retrotransposon integration upstream of tRNA genes. EMBO Journal, 2020, 39 (17), pp.e104337. ⟨10.15252/embj.2019104337⟩. ⟨hal-03066142⟩
Accès au texte intégral et bibtex
https://hal.science/hal-03066142/file/Asif-Laidin%20et%20al._EMBO%20J_2020.pdf BibTex
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Camille Grison, Indranil Adhya, Rachid Menouni, Hélène Fayol, Noé Palmic, et al.. A small targeting domain in Ty1 integrase is sufficient to direct retrotransposon integration upstream of tRNA genes. EMBO Journal, 2020, pp.e104337. ⟨10.15252/embj.2019104337⟩. ⟨hal-02903063⟩
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Gabrielle Bourgeois, Jérôme Seguin, Morgan Babin, Muriel Gondry, Yves Mechulam, et al.. Structural basis of the interaction between cyclodipeptide synthases and aminoacylated tRNA substrates. RNA (New York, N.Y.), 2020, ⟨10.1261/rna.075184.120⟩. ⟨hal-02907478⟩
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https://hal.science/hal-02907478/file/RNA-2020-Bourgeois-1589-602.pdf BibTex
ref_biblio
Nicolas Canu, Carine Tellier, Morgan Babin, Robert Thai, Inès Ajel, et al.. Flexizyme-aminoacylated shortened tRNAs demonstrate that only the aminoacylated acceptor arms of the two tRNA substrates are required for cyclodipeptide synthase activity. Nucleic Acids Research, 2020, 48 (20), ⟨10.1093/nar/gkaa903⟩. ⟨hal-02978046⟩
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ref_biblio
Nicolas Canu, Mireille Moutiez, Pascal Belin, Muriel Gondry. Cyclodipeptide synthases: a promising biotechnological tool for the synthesis of diverse 2,5-diketopiperazines. Natural Product Reports, 2020, ⟨10.1039/c9np00036d⟩. ⟨hal-02415937⟩
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Fabien Le Chevalier, Isabelle Correia, Lucrèce Matheron, Morgan Babin, Mireille Moutiez, et al.. In vivo characterization of the activities of novel cyclodipeptide oxidases: new tools for increasing chemical diversity of bioproduced 2,5-diketopiperazines in Escherichia coli. Microbial Cell Factories, 2020, 19 (1), pp.178. ⟨10.1186/s12934-020-01432-y⟩. ⟨hal-02944247⟩
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2019

Journal articles

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Pavlina Dubois, Isabelle Correia, Fabien Le Chevalier, Steven Dubois, Isabelle Jacques, et al.. Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids. Scientific Reports, 2019, 9 (1), pp.9208. ⟨10.1038/s41598-019-45519-y⟩. ⟨hal-03982770⟩
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Jerzy Witwinowski, Mireille Moutiez, Matthieu Coupet, Isabelle Correia, Pascal Belin, et al.. Study of bicyclomycin biosynthesis in Streptomyces cinnamoneus by genetic and biochemical approaches. Scientific Reports, 2019, 9 (1), pp.20226. ⟨10.1038/s41598-019-56747-7⟩. ⟨hal-02431235⟩
Accès au texte intégral et bibtex
https://hal.science/hal-02431235/file/2019_Study%20of%20bicyclomycin%20biosynthesis%20in%20Streptomyces%20cinnamoneusby%20genetic%20and%20biochemical%20approaches.pdf BibTex
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Pavlina Dubois, Isabelle Correia, Fabien Le Chevalier, Steven Dubois, Isabelle Jacques, et al.. Author Correction: Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids. Scientific Reports, 2019, 9 (1), pp.15009. ⟨10.1038/s41598-019-51404-5⟩. ⟨hal-02321505⟩
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2018

Journal articles

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Emmanuelle Schmitt, Gabrielle Bourgeois, Muriel Gondry, Alexey Aleksandrov. Cyclization Reaction Catalyzed by Cyclodipeptide Synthases Relies on a Conserved Tyrosine Residue. Scientific Reports, 2018, 8 (1), pp.7031. ⟨10.1038/s41598-018-25479-5⟩. ⟨hal-01974171⟩
Accès au texte intégral et bibtex
https://polytechnique.hal.science/hal-01974171/file/41598_2018_Article_25479.pdf BibTex
ref_biblio
Gabrielle Bourgeois, Jérôme Seguin, Morgan Babin, Pascal Belin, Mireille Moutiez, et al.. Structural basis for partition of the cyclodipeptide synthases into two subfamilies. Journal of Structural Biology, 2018, 203 (1), pp.17-26. ⟨10.1016/j.jsb.2018.03.001⟩. ⟨hal-01969469⟩
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Nicolas Canu, Pascal Belin, Robert Thai, Isabelle Correia, Olivier Lequin, et al.. Incorporation of non-canonical amino acids into 2,5-diketopiperazines by cyclodipeptide synthases. Angewandte Chemie International Edition, 2018, 57 (12), pp.3118-3122. ⟨10.1002/anie.201712536⟩. ⟨cea-01988447⟩
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ref_biblio
Muriel Gondry, Isabelle Jacques, Robert Thai, Morgan Babin, Nicolas Canu, et al.. A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes. Frontiers in Microbiology, 2018, 9, pp.46. ⟨10.3389/fmicb.2018.00046⟩. ⟨cea-01988448⟩
Accès au texte intégral et bibtex
https://cea.hal.science/cea-01988448/file/A%20Comprehensive%20Overview%20of%20the%20Cyclodipeptide%20Synthase%20Family%20Enriched%20with%20the%20Characterization%20of%2032%20New%20Enzymes.pdf BibTex