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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Researchers at SIMoS, SPI (DMTS) and BioMaps (SHFJ) report the development of a new molecule, MQ232, derived from mambaquaretin. As a specific antagonist of the vasopressin V2 receptor, MQ232 is a promising drug candidate for the treatment of renal pathologies.
A team from I2BC has proposed a thought experiment -the Next Generation Sequencing chess problem-, which treats sequencing data as a superimposed image of several independent chess games. A more realistic approach to the dynamics of cellular processes within each cell, revealing the limits of NGS approaches to temporal analysis.
Researchers at Li2D (SPI/DMTS, Marcoule) have proposed an innovative tandem mass spectrometry proteotyping method for the universal identification of pathogenic viruses, requiring no prior knowledge of sample composition. A step towards improved diagnosis of viral infections
A team from SIMoS (DMTS) identifies a subtype of sodium channels, expressed in spinal ganglion sensory neurons, as a target involved in the action of crotalphine, an analgesic peptide derived from rattlesnake venom.
Researchers at DMTS and SHFJ have carried out a multiplexed analysis of tumor cells and tissues, based on the use of cleavable therapeutic antibodies carrying mass tags, for the identification and quantification of cancer biomarkers. A proof-of-concept demonstrating the high potential of this tumor immunoprofiling approach
The first data from the QSM4SENIOR project, led by teams from NeuroSpin and VENTIO, have been published in Frontiers in Neuroimaging. They provide a highly accurate map of changes in iron levels during normal brain ageing, a valuable aid for scientists specialising in neurodegenerative diseases.
A team from NeuroSpin has proposed a classification of the morphology of short white matter bundles (SWMBs) in human and chimpanzee brains. A wide variety of shapes was observed, as well as differences. This study provides valuable information on SWMB morphology and its potential implications for human cognitive development
A team from I2BC has studied the regulation of oxygen reduction to superoxide at photosystem I (PSI) in several redox mutants of the plant A.thaliana, grown during different photoperiods. The results enable to propose a new model of PSI-specific redox regulation, capable of rapid adaptation according to light conditions
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.