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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Researchers from the DMTS have developed a method for exploring the chemical exposome in large, complex mass spectrometry datasets. They applied it to the analysis of meconium samples from a cohort.
A team from NeuroSpin investigated the impact of contrasting auditory environments on the morphology of the superior temporal sulcus (STS) in preterm newborns. By showing that exposure to music is associated with a deeper STS, the authors suggest that early auditory experience influences the structural development of temporal brain regions.
A team from NeuroSpin sheds light on the mechanisms underlying artifacts caused by intra-voxel dephasing, which occur when using ultra-high-field MRI acceleration methods such as GRAPPA.
Researchers from BAOBAB (NeuroSpin) have demonstrated that cortical folding is indeed a biomarker of brain development and that its genetic influences can be detected using deep learning methods.
A collaborative study between the BIAM and Joliot (SPI/DMTS) institutes demonstrates the feasibility of near-complete whole-body carbon-13 isotopic labeling in mice and lays the foundation for a global, quantitative, and unbiased metabolomics approach. This unprecedented strategy could also enable the investigation of certain metabolic troubles.
Researchers from the BioMaps laboratory (SHFJ) demonstrate the value of artificial intelligence software in interpreting MRI data for monitoring individuals with multiple sclerosis. However, validation by clinical radiologists remains essential to ensure the accuracy of the interpretation.
DMTS teams have characterised 17 monoclonal antibody-candidates targeting ricin using two original biophysical approaches. The identification of ricin residues involved in functional antibody recognition paves the way for the development of powerful monoclonal therapeutic antibodies against this natural toxin, which is a bioterrorism agent.
A team from I2BC has uncovered the key steps governing the assembly and regulation of iron–sulfur cluster biosynthesis, essential metallic cofactors involved in numerous biological functions. Defects in this process lead to pathologies such as Friedreich’s ataxia. These studies represent major advances toward the development of future therapies.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.