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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
A team from NeuroSpin, in collaboration with researchers from the Sainte-Anne Hospital and from the University of Minho, has developed, using magnetic resonance imaging, a unique set of resources for the analysis and visualization of preclinical data in the rat brain.
NeuroSpin researchers have developed a software for preprocessing non-human primate brain raw images obtained by functional magnetic resonance imaging. The aim is to help harmonize methods, improve procedures, facilitate comparison and interpretation of the acquired images and to minimize the number of animals to be used in research.
Researchers from IRAMIS collaborated with a team from SPI (LERI) for the development of a microfluidic biochip ("lab-on-chip") based on ultra-sensitive magnetic sensors with giant magnetoresistance (GMR sensors), capable of individually and effectively detect magnetically-labeled biological targets.
The European Research Council (ERC) announced, on December 10, 2019, the winners of the 2019 ERC "Consolidator Grants". Three CEA researchers are rewarded for the excellence of their work in astrophysics, particle physics and chemistry. In Joliot, chemistry is honored with the award of the research grant to Davide Audisio, SCBM, for his expertise in labeling molecules of interest with 14Carbone.
A team from SCBM, in collaboration with Mauritian modelers, has shown that carboxylic acids can be easily converted into small rings with four carbon atoms, the cyclobutanes, using blue LEDs and an iridium catalyst. Cyclobutanes are increasingly used in the design of new drugs and the method described here will help to significantly expand the chemical space explored in "drug discovery".
A team from SIMoS (DMTS) developed, as part of a collaborative study, the first 99mTc-labeled radiotracer specific for an extracellular enzyme, MMP-12, overexpressed in many inflammatory processes, including abdominal aortic aneurysm. This radiotracer, which preferentially marks the aneurysm in an animal model, will be a promising tool for molecular imaging of the various pathologies in which MMP-12 is involved.
A team from SPI, in collaboration with the metabolic biochemistry service and the Institute of Memory and Alzheimer's Disease (IM²A) of the university hospitals Pitié-Salpêtrière, has developed a method for the simultaneous quantification of tau and α-synuclein proteins in human cerebrospinal fluid by high-resolution mass spectrometry. A promising new approach for the differential diagnosis of Lewy bodies dementia and Alzheimer's disease.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.