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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
The Fresnel Institute, in collaboration with the University of St Petersburg and a team from NeuroSpin, has developed a new ceramic resonator (probe) suitable for 17T magnetic resonance microscopy, i.e. for spatial resolutions below 100 μm3. This probe allows the production of MRI images with a signal-to-noise ratio 2 times greater than those obtained with reference probes, in copper.
Two teams from JOLIOT (SPI / SCBM), in collaboration with the University of Cincinnati, confirm the interest of a drug candidate to treat the congenital creatine deficiency syndrome, a rare neurological childhood disease, responsible for developmental delays and intellectual disability. The results obtained in an animal model of the disease show that it is possible to administer, nasally, dodecyl creatine ester-loaded microspheres, thus improving the cognitive functions of treated animals.
The French National Infrastructure of Integrated Structural Biology (FRISBI) is now integratinf Genopole's structural biology platform into its Paris-Sud node.
A team of NeuroSpin (GIN Bordeaux), within a multidisciplinary consortium, led an exploratory study of whole genome sequencing to search for rare genetic mutations that may be implicated in the atypical inverted right-hemispheric dominance for language (DLAtyp), present in less than 1% of the adult population. A higher rate of mutations affecting the actin cytoskeleton was revealed in DLAtyp individuals identified by functional MRI.
The M-CUBE consortium, funded by the H2020 program, is now listed in the "success stories" of the European Commission website. A further confirmation of the interest of the work of NeuroSpin physicits and their collaborators on metamaterials to "boost" the MRI of the future.
A collaboration involving NeuroSpin sheds new light on the action of lithium in bipolar disorder. The modeling (NODDI) of water diffusion measured by diffusion MRI allowed analysis of cerebral microstructure. Results indicate increased dendritic density in the frontal cortex of lithium-treated patients. This suggests that an improved communication between neurons in this region of the brain may underlie the beneficial effects of lithium in bipolar disorder.
A team from NeuroSpin, in collaboration with Maastricht and Minnesota universities, conducted for the first time an entire functional MRI exam based on 7T parallel transmission technology, as part of the Human Connectome Project. The results show that the problem of radiofrequency field inhomogeneities, a barrier to the full exploitation of very high-field MRI, is thus correctly solved, without any additional cost for the user.
Imaging the brain of a patient at the microscopic scale is as of yet not possible but might turn into a reality thanks to a new tool for creating virtual biopsies. This algorithm has been developed by a team of NeuroSpin (CEA-Joliot) in collaboration with the Institute of NeuroScience and Medicine of Juelich as part of the European Human Brain Project. A first study demontrsating the potentiel of the algorithm ot simulate white matter samples has been published in NeuroImage.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.