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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
A team of SB2SM (I2BC@Saclay), in collaboration with the universities of South-Paris and Rennes1, has developed a new, particularly effective catalyst for the reduction of carbon dioxide (CO2), directly inspired by nature. Results are published in Angewandte Chemie.
An international collaboration led by a team from the ICM (Brain and Spine Institute) shows that it is possible to assess states of consciousness through an imaging process developed at NeuroSpin. This new tool could help to better diagnose alterations of consciousness. The results were published in Science Advances.
A team from SHFJ proposes a predictive model that corrects the "acquisition center" effect thanks to an unprecedented harmonization method in medical imaging.
Researchers from SPI, in collaboration with teams from an European foundation, EF Clif, carried out global and targeted metabolomic analyzes which made possible to highlight, in cirrhotic patients, an activation of the kynurenine metabolic pathway (tryptophan degradation pathway). The imbalance of this pathway is probably the cause of the symptoms observed during cirrhotic decompensation, when the body can no longer compensate for liver dysfunctions.
Europe is committed to better diagnostic and therapeutic management of patients with severe forms of cirrhosis. It finances the MICROB-PREDICT consortium, which aims to better understand the role of the human microbiome in the pathogenesis and evolution of cirrhosis. Final goal is to uture personalized therapeutic strategies and diagnostic tools. The SPI (Joliot Institute) is the main project lead for the CEA.
By using in vivo MRI, researchers at NeuroSpin (GIN-Bordeaux) have been able to evaluate the myelination of nerve fibers in the auditory cortex, area of the brain involved in the processing of language sounds. They observed an asymmetry of myelination in favor of the left hemisphere, in particular according to language performances. They show the usefulness of neuroimaging markers in the study of structure-function relationships at the cerebral cortex level.
Helicenes are synthetic molecules with attractive properties for physicists expert in materials but also for biologists. A collaboration led by chemists from the SCBM (CEA-Joliot) and involving the NIMBE (CEA-Iramis) allowed the synthesis of a particular class of helicenes.
A partnership between the François Jacob Institute of Biology/CEA, The Frédéric Joliot Institute for Life Sciences/CEA and CellTechs (a Sup'Biotech lab) has led to a new approach for modeling Alzheimer's disease in vitro.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.