To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Scientific result | Chemistry | Cancer | Nanomedicine
A team from the SCBM, in collaboration with the SPI, the IC2MP and the University Hospital of Poitiers, has developed a bioorthogonal chemistry strategy that allows, in vivo, the controlled release of active ingredients contained in micelles-targeting cancerous tumors. These results pave the way for new strategies for targeted drug delivery.
A bioorthogonal approach is explored to release the content of nanoparticles on demand. Exploiting our recently described click‐and‐release technology, we developed a new generation of cleavable micelles able to disassemble through a sequential enzymatic and bioorthogonal activation process. Proof‐of‐concept experiments showed that this new approach could be successfully used to deliver the substances encapsulated into micelles in living cells as well as in mice by two complementary targeted strategies.
Karine Porte, Brigitte Renoux, Elodie Péraudeau, Jonathan Clarhaut, Balkis Eddhif, Pauline Poinot, Edmond Gravel, Eric Doris, Anne Wijkhuisen, Davide Audisio, Sébastien Papot and Frédéric Taran. Controlled Release of Micelle Payload via Sequential Enzymatic and Bioorthogonal Reactions in Living Systems (2019) Angewandte Chemie Int. Ed. http://dx.doi.org/10.1002/anie.201902137
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.