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Scientific result | Chemistry | Nanosciences | Nanomedicine
As part of a collaboration with MIRCen (Jacob Institute), researchers of SCBM have developed functional micellar vectors that can effectively target tumors and whose therapeutic activity is intrinsically carried by the constitutive unit of the micelle. This combination leads to better drug load and avoids premature drug release.
Abstract of the original paper
Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic PEG unit and a hydrophobic stearyl chain. The epipodophyllotoxin-containing amphiphiles were assembled into the corresponding micelles which were evaluated in vivo for their tumor targeting properties.
J. Alliot, I. Theodorou, D.V. Nguyen, C. Forier, F. Ducongé, E. Gravel, E. Doris.Tumor targeted micellar nanocarriers assembled from Epipodophyllotoxin-based amphiphiles. Nanoscale, 2019, 11, 9756-9759 http://dx.doi.org/10.1039/c9nr01068h
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.