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Laboratory | Bioinformatic | Genomics | Epigenetics
Transcriptional Regulation of Genomes
The group is interested in molecular mechanisms of eukaryotic transcriptional regulation in vivo on the genomic scale. The Mediator complex, essential for regulation of transcription by RNA polymerase II, is central for our projects. We use the budding yeast Saccharomyces cerevisiae and human cells as our biological models and apply integrative approaches to understand how the transcriptional regulation works and how transcription is coordinated with others nuclear processes like DNA repair.
This team is part of I2BCVersion Française
Our two-hybrid screening with Mediator subunits permits us to uncover a number of interactions between Mediator and other components of the nucleus (unpublished data). One particularly interesting interaction that we have identified is the contact between one of the Mediator subunits and a DNA repair protein. We uncovered a new role of Mediator by connecting transcription and DNA repair via this direct contact with Rad2 endonuclease, the yeast homolog of human XPG protein. Mutations in human XPG gene give rise to a xeroderma pigmentosum (XP) associated with Cockayne syndrome (CS) disease. Our results indicated that Mediator is involved in transcription-coupled DNA repair by facilitating Rad2 recruitment to transcribed genes. We propose that in addition to its fundamental coactivator role, Mediator acts in essential nuclear processes beyond transcription.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.