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Selected publications (2021-2011) of the team "Toxins, transport and therapeutic innovation"

Published on 29 April 2022

  • Kali, S., Jallet, C., Azebi, S., Cokelaer, T., Da Fonseca, J. P., Wu, Y., Barbier, J., Cintrat, J.-C., Gillet, D., & Tordo, N. (2021). Broad spectrum compounds targeting early stages of rabies virus (RABV) infection. Antiviral Research188, 105016. https://doi.org/10.1016/j.antiviral.2021.105016
  • Pomel, S., Cojean, S., Pons, V., Cintrat, J.-C., Nguyen, L., Vacus, J., Pruvost, A., Barbier, J., Gillet, D., & Loiseau, P. M. (2021). An adamantamine derivative as a drug candidate for the treatment of visceral  leishmaniasis. The Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dkab226
  • Johansson, K., Willysson, A., Kristoffersson, A.-C., Tontanahal, A., Gillet, D., Ståhl, A.-L., & Karpman, D. (2020). Shiga Toxin-Bearing Microvesicles Exert a Cytotoxic Effect on Recipient Cells Only  When the Cells Express the Toxin Receptor. Frontiers in Cellular and Infection Microbiology10, 212. https://doi.org/10.3389/fcimb.2020.00212
  • Abdelkafi, H., Michau, A., Pons, V., Ngadjeua, F., Clerget, A., Ait Ouarab, L., Buisson, D.-A., Montoir, D., Caramelle, L., Gillet, D., Barbier, J., & Cintrat, J.-C. (2020). Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin. Journal of Medicinal Chemistry63(15), 8114–8133. https://doi.org/10.1021/acs.jmedchem.0c00298
  • Willysson, A., Ståhl, A.-L., Gillet, D., Barbier, J., Cintrat, J.-C., Chambon, V., Billet, A., Johannes, L., & Karpman, D. (2020). Shiga Toxin Uptake and Sequestration in Extracellular Vesicles Is Mediated by Its  B-Subunit. Toxins12(7). https://doi.org/10.3390/toxins12070449
  • Forrester, A., Rathjen, S. J., Daniela Garcia-Castillo, M., Bachert, C., Couhert, A., Tepshi, L., Pichard, S., Martinez, J., Munier, M., Sierocki, R., Renard, H. F., Augusto Valades-Cruz, C., Dingli, F., Loew, D., Lamaze, C., Cintrat, J. C., Linstedt, A. D., Gillet, D., Barbier, J., & Johannes, L. (2020). Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2. Nature Chemical Biology16(3), 327–336. https://doi.org/10.1038/s41589-020-0474-4
  • Mahtal, N., Wu, Y., Cintrat, J. C., Barbier, J., Lemichez, E., & Gillet, D. (2020). Revisiting old ionophore lasalocid as a novel inhibitor of multiple toxins. Toxins12(1), 1–13. https://doi.org/10.3390/toxins12010026
  • Wu, Y., Boulogne, C., Carle, S., Podinovskaia, M., Barth, H., Spang, A., Cintrat, J. C., Gillet, D., & Barbier, J. (2020). Regulation of endo-lysosomal pathway and autophagic flux by broad-spectrum antipathogen inhibitor ABMA. FEBS Journal, 1–16. https://doi.org/10.1111/febs.15201
  • Wu, Y., Pons, V., Noël, R., Kali, S., Shtanko, O., Davey, R. A., Popoff, M. R., Tordo, N., Gillet, D., Cintrat, J. C., & Barbier, J. (2019). DABMA: A Derivative of ABMA with improved broad-spectrum inhibitory activity of toxins and viruses. ACS Medicinal Chemistry Letters10(8), 1140–1147. https://doi.org/10.1021/acsmedchemlett.9b00155
  • Mahtal, N., Brewee, C., Pichard, S., Visvikis, O., Cintrat, J. C., Barbier, J., Lemichez, E., & Gillet, D. (2018). Screening of a Drug Library Identifies Inhibitors of Cell Intoxication by CNF1. ChemMedChem13(7), 754–761. https://doi.org/10.1002/cmdc.201700631
  • Barbier, J., & Gillet, D. (2018). Ribosome inactivating proteins: From plant defense to treatments against human misuse or diseases. Toxins10(4), 10–13. https://doi.org/10.3390/toxins10040160
  • Shtanko, O., Sakurai, Y., Reyes, A. N., Noël, R., Cintrat, J. C., Gillet, D., Barbier, J., & Davey, R. A. (2018). Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection. Antiviral Research149(November 2017), 154–163. https://doi.org/10.1016/j.antiviral.2017.11.016
  • Dai, W., Wu, Y., Bi, J., Wang, S., Li, F., Kong, W., Barbier, J., Cintrat, J. C., Gao, F., Gillet, D., Su, W., & Jiang, C. (2018). Antiviral effects of abma against herpes simplex virus type 2 in vitro and in vivo. Viruses10(3), 1–15. https://doi.org/10.3390/v10030119
  • Wu, Y., Pons, V., Goudet, A., Panigai, L., Fischer, A., Herweg, J. A., Kali, S., Davey, R. A., Laporte, J., Bouclier, C., Yousfi, R., Aubenque, C., Merer, G., Gobbo, E., Lopez, R., Gillet, C., Cojean, S., Popoff, M. R., Clayette, P., … Barbier, J. (2017). ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments. Scientific Reports7(1), 1–13. https://doi.org/10.1038/s41598-017-15466-7
  • Dai, W., Wu, Y., Bi, J., Lu, X., Hou, A., Zhou, Y., Sun, B., Kong, W., Barbier, J., Cintrat, J. C., Gao, F., Gillet, D., Su, W., & Jiang, C. (2017). Antiviral effects of Retro-2cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo. Antiviral Research144, 311–321. https://doi.org/10.1016/j.antiviral.2017.07.001
  • Gupta, N., Noël, R., Goudet, A., Hinsinger, K., Michau, A., Pons, V., Abdelkafi, H., Secher, T., Shima, A., Shtanko, O., Sakurai, Y., Cojean, S., Pomel, S., Liévin-Le Moal, V., Leignel, V., Herweg, J. A., Fischer, A., Johannes, L., Harrison, K., … Gillet, D. (2017). Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales. Chemico-Biological Interactions267, 96–103. https://doi.org/10.1016/j.cbi.2016.10.005
  • Herweg, J. A., Pons, V., Becher, D., Hecker, M., Krohne, G., Barbier, J., Berger, H., Rudel, T., & Mehlitz, A. (2016). Proteomic analysis of the Simkania-containing vacuole: The central role of retrograde transport. Molecular Microbiology99(1), 151–171. https://doi.org/10.1111/mmi.13222
  • Yang, B., Ming, X., Abdelkafi, H., Pons, V., Michau, A., Gillet, D., Cintrat, J. C., Barbier, J., & Juliano, R. (2016). Retro-1 Analogues Differentially Affect Oligonucleotide Delivery and Toxin Trafficking. ChemMedChem11(22), 2506–2510. https://doi.org/10.1002/cmdc.201600463
  • Barbier, J., Cintrat, J. C., & Gillet, D. (2016). Intracellular pathogens convert macrophages from death traps into hospitable homes. FEBS Journal283(4), 595–597. https://doi.org/10.1111/febs.13657
  • Nonnenmacher, M. E., Cintrat, J. C., Gillet, D., & Weber, T. (2015). Syntaxin 5-dependent retrograde transport to the trans-Golgi network is required for adeno-associated virus transduction. J Virol89(3), 1673–1687. https://doi.org/10.1128/JVI.02520-14
  • Abdelkafi, H., Michau, A., Clerget, A., Buisson, D. A., Johannes, L., Gillet, D., Barbier, J., & Cintrat, J. C. (2015). Synthesis, Chiral Separation, Absolute Configuration Assignment, and Biological Activity of Enantiomers of Retro-1 as Potent Inhibitors of Shiga Toxin. ChemMedChem10(7), 1153–1156. https://doi.org/10.1002/cmdc.201500139
  • Secher, T., Shima, A., Hinsinger, K., Cintrat, J. C., Johannes, L., Barbier, J., Gillet, D., & Oswald, E. (2015). Retrograde trafficking inhibitor of Shiga toxins reduces morbidity and mortality of mice infected with enterohemorrhagic Escherichia coli. Antimicrobial Agents and Chemotherapy59(8), 5010–5013. https://doi.org/10.1128/AAC.00455-15
  • Gupta, N., Pons, V., Noël, R., Buisson, D. A., Michau, A., Johannes, L., Gillet, D., Barbier, J., & Cintrat, J. C. (2014). (S)-N-methyldihydroquinazolinones are the active enantiomers of retro-2 derived compounds against toxins. ACS Medicinal Chemistry Letters5(1), 94–97. https://doi.org/10.1021/ml400457j
  • Noel, R., Gupta, N., Pons, V., Goudet, A., Garcia-Castillo, M. D., Michau, A., Martinez, J., Buisson, D. A., Johannes, L., Gillet, D., Barbier, J., & Cintrat, J. C. (2013). N -Methyldihydroquinazolinone derivatives of retro-2 with enhanced efficacy against shiga toxin. Journal of Medicinal Chemistry56(8), 3404–3413. https://doi.org/10.1021/jm4002346
  • Ming, X., Carver, K., Michael Fisher, Romain Noel, Cintrat, J. C., Gillet, D., Barbier, J., Cao, C., Bauman, J., & Juliano, R. L. (2013). The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides. Nucleic Acids Research41(6), 3673–3687. https://doi.org/10.1093/nar/gkt066
  • Barbier, J., Bouclier, C., Johannes, L., & Gillet, D. (2012). Inhibitors of the cellular trafficking of ricin. Toxins4(1), 15–27. https://doi.org/10.3390/toxins4010015
  • Stechmann, B., Bai, S. K., Gobbo, E., Lopez, R., Merer, G., Pinchard, S., Panigai, L., Tenza, D., Raposo, G., Beaumelle, B., Sauvaire, D., Gillet, D., Johannes, L., & Barbier, J. (2010). Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell141(2), 231–242. https://doi.org/10.1016/j.cell.2010.01.043