​The RESIST Laboratory is located on the Bicêtre Hospital site. Its research activities focus on understanding the mechanisms of antibiotic resistance, particularly β-lactam resistance in Gram-negative bacilli.

Characterization of Novel β-Lactam Resistance Mechanisms

For over thirty years, RESIST team has been investigating the emergence of β-lactam resistance mechanisms in Gram-negative bacilli, including Enterobacterae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our work involves the genetic analysis of elements involved in the acquisition of resistance, as well as the biochemical characterization of enzymes responsible for β-lactam hydrolysis.

Epidemiology of Resistance

RESIST Team is also engaged in studying the epidemiology of resistance and the clonal lineages or vectors involved in its dissemination. Through the French National Reference Center (CNR) for carbapenem resistance in Enterobacterales, directed by Prof. Laurent Dortet and Dr. Rémy Bonnin, the team has access to multidrug-resistant clinical isolates in France, including overseas territories. Genomic analyses of these strains enable high-resolution monitoring of emerging resistance mechanisms and associated clones.

Development of Diagnostic Tests and Evaluation of Novel Compounds

RESIST team is also involved in the development and evaluation of new resistance detection assays and in the assessment of the efficacy of novel antibiotic compounds. Leveraging an extensive collection of multidrug-resistant strains and expertise in enzymology and microbiology, RESIST team tests diagnostic tools based on various approaches (e.g., molecular, immunochromatographic) as well as new antibiotics or β-lactamase inhibitors.​