 | | Orchestration of human multi-lineage hematopoietic cell development by humanized in vivo bone marrow models | Renou L, Sun W, Friedrich C, Galant K, Conrad C, Consalus A, Plantier E, Schallmoser K, Krisch L, Barroca V, Devanand S, Dechamps N, Reinisch A, Martinovic J, Magnani A, Faivre L, Lewandowski D, Calvo J, Perie L, Kosmider O, Pflumio F
| | | | | Progressive chromatin rewiring by ETO2::GLIS2 revealed in a genome-edited human iPSC model of pediatric leukemia initiation | Boudia F, Baille M, Babin L, Aid Z, Robert E, Rivière J, Galant K, Alonso-Pérez V, Anselmi L, Arkoun B, Abermil N, Marzac C, Bertuccio SN, de Prémesnil A, Lopez CK, Eeckhoutte A, Naimo A, Leite B, Catelain C, Metereau C, Gonin P, Gaspar N, Schwaller J, Bernard OA, Raslova H, Gaudry M, Marchais A, Lapillonne H, Petit A, Pflumio F, Arcangeli ML, Brunet E, Mercher T
| | | | | High CD44 expression and enhanced E-selectin binding identified as biomarkers of chemoresistant leukemic cells in human T-ALL | Calvo J, Naguibneva I, Kypraios A, Gilain F, Uzan B, Gaillard B, Bellenger L, Renou L, Antoniewski C, Lapillonne H, Petit A, Ballerini P, Mancini SJ, Marchand T, Peyron JF, Pflumio F
| | | | | The AXL inhibitor bemcentinib overcomes microenvironment-mediated resistance to pioglitazone in acute myeloid leukemia | Zhu J, Guérineau H, Lefebvre-Fortané AM, Largeaud L, Lambert J, Rousselot P, Boudouin M, Calvo J, Prost S, Clauser S, Bardet V
| | | | | Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia | Alonso-Pérez V, Galant K, Boudia F, Robert E, Aid Z, Renou L, Barroca V, Devanand S, Babin L, Rouiller-Fabre V, Moison D, Busso D, Piton G, Metereau C, Abermil N, Ballerini P, Hirsch P, Haddad R, Martinovic J, Petit A, Lapillonne H, Brunet E, Mercher T, Pflumio F
| | | | | Multiple Mechanisms of Action of Sulfodyne®, a Natural Antioxidant, against Pathogenic Effects of SARS-CoV-2 Infection | Romeo PH, Conquet L, Messiaen S, Pascal Q, Moreno SG, Bravard A, Bernardino-Sgherri J, Dereuddre-Bosquet N, Montagutelli X, Le Grand R, Petit V, Ferri F
| | | | | T-cell acute lymphoblastic leukemia progression is supported by inflammatory molecules including hepatocyte growth factor | Le Maout C, Fahy L, Renou L, Devanand C, Duwat C, Barroca V, Le Gall M, Ballerini P, Petit A, Calvo J, Uzan B, Pflumio F, Petit V
| | | | | The ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300-dependent stemness program | Fagnan A, Aid Z, Baille M, Drakul A, Robert E, Lopez CK, Thirant C, Lecluse Y, Rivière J, Ignacimouttou C, Salmoiraghi S, Anguita E, Naimo A, Marzac C, Pflumio F, Malinge S, Wichmann C, Huang Y, Lobry C, Chaumeil J, Soler E, Bourquin JP, Nerlov C, Bernard OA, Schwaller J, Mercher T
| | | | | CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia | Cardoso BA, Duque M, Gírio A, Fragoso R, Oliveira ML, Allen JR, Martins LR, Correia NC, Silveira AB, Veloso A, Kimura S, Demoen L, Matthijssens F, Jeha S, Cheng C, Pui CH, Grosso AR, Neto JL, De Almeida SF, Van Vlieberghe P, Mullighan CG, Yunes JA, Langenau DM, Pflumio F, Barata JT
| | | | | Identifying Candidate Gene Drivers Associated with Relapse in Pediatric T-Cell Acute Lymphoblastic Leukemia Using a Gene Co-Expression Network Approach | Kypraios A, Bennour J, Imbert V, David L, Calvo J, Pflumio F, Bonnet R, Couralet M, Magnone V, Lebrigand K, Barbry P, Rohrlich PS, Peyron JF
| | | | | The Antioxidant TEMPOL Protects Human Hematopoietic Stem Cells From Culture-Mediated Loss of Functions | Elia Henry, Frédéric Picou, Vilma Barroca, Nathalie Dechamps, Steicy Sobrino, Emmanuelle Six, Camille Gobeaux, Patrick Auberger, Olivier Hérault, Françoise Pflumio, Marie-Laure Arcangeli | | | | | A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors | Marques Da Costa ME, Zaidi S, Scoazec JY, Droit R, Lim WC, Marchais A, Salmon J, Cherkaoui S, Morscher RJ, Laurent A, Malinge S, Mercher T, Tabone-Eglinger S, Goddard I, Pflumio F, Calvo J, Redini F, Entz-Werlé N, Soriano A, Villanueva A, Cairo S, Chastagner P, Moro M, Owens C, Casanova M, Hladun-Alvaro R, Berlanga P, Daudigeos-Dubus E, Dessen P, Zitvogel L, Lacroix L, Pierron G, Delattre O, Schleiermacher G, Surdez D, Geoerger B. | | | | | In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis. | Matos-Rodrigues G, Barroca V, Muhammad AA, Dardillac E, Allouch A, Koundrioukoff S, Lewandowski D, Despras E, Guirouilh-Barbat J, Frappart L, Kannouche P, Dupaigne P, Le Cam E, Perfettini JL, Romeo PH, Debatisse M, Jasin M, Livera G, Martini E & Lopez BS. | | | | | Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration | Dushime H, Moreno SG, Linard C, Adrait A, Couté Y, Peltzer J, Messiaen S, Torres C, Bensemmane L, Lewandowski D, Romeo PH, Petit V, Gault N
| | | | | Beta-Catenin and its new partner FOXO3 shake T-ALL | | | | | | Melanophages give rise to hyperreflective foci in AMD, a disease-progression marker | Augustin S, Lam M, Lavalette S, Verschueren A, Blond F, Forster V, Przegralek L, He Z, Lewandowski D, Bemelmans AP, Picaud S, Sahel JA, Mathis T, Paques M, Thuret G, Guillonneau X, Delarasse C, Sennlaub F | | | | | High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2::GLIS2 pediatric leukemia. | Aid Z, Robert E, Lopez CK, Bourgoin M, Boudia F, Le Mene M, Riviere J, Baille M, Benbarche S, Renou L, Fagnan A, Thirant C, Federici L, Touchard L, Lecluse Y, Jetten A, Geoerger B, Lapillonne H, Solary E, Gaudry M, Meshinchi S, Pflumio F, Auberger P, Lobry C, Petit A, Jacquel A, Mercher T | | | | | CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia. | Allouch A, Voisin L, Zhang Y, Syed R, Lecluse Y, Calvo J, Sélimoglu-Buet D, De Botton S, Louache F, Pflumio F, Solary E, Perfettini JL | | | | | Concurrent CDX2 cis-deregulation and UBTF-ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL. | Passet M, Kim R, Gachet S, Sigaux F, Chaumeil J, Galland A, Sexton T, Quentin S, Hernandez L, Larcher L, Bergugnat H, Ye T, Karasu N, Caye-Eude A, Heizmann B, Duluc I, Chevallier P, Rousselot P, Huguet F, Leguay TT, Hunault-Berger MM, Pflumio F, Freund JN, Lobry C, Lheritier V, Dombret H, Domon-Dell C, Soulier J, Boissel N, Clappier E | | | | | Deleterious effect of bone marrow-resident macrophages on hematopoietic stem cells in response to total body irradiation. | Chalot M, Barroca V, Devanand S, Hoffschir F, Romeo PH, Moreno SG | | | | | In vivo monitoring of Polycythemia Vera development reveals carbonic anhydrase 1 as a potent therapeutic target. | Murakami S, Barroca V, Perie L, Bravard A, Bernardino-Sgherri J, Tisserand A, Devanand C, Edmond V, Magniez A, Tenreira Bento S, Torres C, Pasquier F, Plo I, Vainchenker W, Villeval JL, Romeo PH, Lewandowski D | | | | | MXD4/MAD4 Regulates Human Keratinocyte Precursor Fate. | Coutier J, Auvré F, Lemaître G, Lataillade JJ, Deleuze JF, Roméo PH, Martin MT, Fortunel NO | | | | | REDD1 is a gatekeeper of murine hematopoietic stem cell functions during stress responses. | Barroca V, Henry E, Dechamps N, Renou L, Chaintreuil P, Kulkarni R, Devanand S, Jacquel A, Robert G, Auberger P, Pflumio F, Arcangeli ML | | | | | A DL-4- and TNF?-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors. | Moirangthem RD, Ma K, Lizot S, Cordesse A, Olivré J, de Chappedelaine C, Joshi A, Cieslak A, Tchen J, Cagnard N, Asnafi V, Rausell A, Simons L, Zuber J, Taghon T, Staal FJT, Pflumio F, Six E, Cavazzana M, Lagresle-Peyrou C, Soheili T, André I | | | | | Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia. | Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV. | | | | | How Hematopoietic Stem Cells Respond to Irradiation: Similarities and Differences between Low and High Doses of Ionizing Radiations | | | | | | JAM-C/Jam-C Expression Is Primarily Expressed in Mouse Hematopoietic Stem Cells. | Henry E, Barroca V, Lopez CK, Aurrand-Lions M, Lewandowski D, Mercher T, Arcangeli ML | | | | | Piezo1-xerocytosis red cell metabolome shows impaired glycolysis and increased hemoglobin oxygen affinity | Kiger L, Oliveira L, Guitton C, Bendélac L, Ghazal K, Proulle V, Galacteros F, Junot C, Fenaille F, Roméo PH, Garçon L, Picard V | | | | | Mouse model of radiation-induced premature ovarian insufficiency reveals compromised oocyte quality: implications for fertility preservation. | Puy V, Barroca V, Messiaen S, Ménard V, Torres C, Devanand C, Moison D, Lewandowski D, Guerquin MJ, Martini E, Frydman N, Livera G. | | | | | Hypoxia favors chemoresistance in T-ALL through a HIF1-mediated mTORC1 inhibition loop | L Fahy, J Calvo, S Chabi, L Renou, C Le Maout, S Poglio, T Leblanc, A Petit, A Baruchel, P Ballerini, I Naguibneva, R Haddad, ML Arcangeli, F Mazurier, F Pflumio* and B Uzan | | |
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