You are here : Home > Research Centers and Units > DRCM > UMR SGSCR > Laboratory for the study of niche, cancer and radiation in haematopoiesis - LENCRH

Laboratory for the study of niche, cancer and radiation in haematopoiesis - LENCRH

​​​​ Laboratoire des cellules Souches Hématopoïétiques et des Leucémies - LSHL
Published on 23 October 2025
​​​
​​​
​
​






Blood cells are generated through the proliferation and differentiation of a small pool of cells known as hematopoietic stem and progenitor cells.

​Pflumio V2.JPG

Françoise PFLUMIO
Principal Investigator
Tél : +33 (0)1 4​6 54 86 17

Secrétariat:
Aurélie GOURET
Tél : +33 (0)1 46 54 98 66
​ ​​

Hematopoietic stem/progenitor cells are character​ized by their quiescence, self-renewal capacity, and multipotency—properties regulated by a combination of intrinsic and extrinsic factors.​

Most blood cancers, including leukemias, originate in the bone marrow. These leukemias are extremely diverse—there are at least as many subtypes as there are blood cell types. Their leukemic transformation results from a combination of genomic abnormalities (mutations, translocations, etc.) that alter the expansion, survival, and differentiation of normal blood cells, and extrinsic signals from the bone marrow niches.

The ENCRH team/laboratory explores interactions between bone marrow niches and normal and pathological hematopoietic cells. LENCRH also develops innovative strategies against acute radiation syndromes and designs preclinical approaches to improve leukemia treatments and post-transplant regeneration, integrating immunocompetent and humanized immunodeficient preclinical models, cell therapies, and clinical collaborations.

LSHL-11.png
​

​

RESEARCH TOPICS

​

Research Projects Focus On​

​1. ​​Deepening the link between the bone marrow microenvironment and leukemic development in T-cell acute lymphoblastic leukemias (T-ALL). Recent results show an important role of specific cells and molecules secreted by the marrow niche in T-ALL development, requiring a more precise definition of the cellular and molecular components involved.

Project leader: Julien Calvo (Researcher, julien.calvo@cea.fr); Project members: L. Renou (Research Engineer​, laurent.renou@cea.fr), D. Lewandowski (Researcher, Daniel.lewandowski@cea.fr), T. Taibi (PhD student), F. Gilain (Research Engineer – fixed-term), J. Tuil (fixed-term).

2. Studying the consequences of gene fusions found in association with pediatric myeloid leukemias in human hematopoietic stem and progenitor cells, and the impact of bone marrow signals on leukemic transformation and propagation.

Project leaders: Francoise Pflumio (Research Director, francoise.pflumio@cea.fr) and Stéphanie Gachet (Researcher, stephanie.gachet@cea.fr) ; Project members: L. Renou (Research Engineer), L. André (Master 2)
In collaboration with T. Mercher’s team, Gustave Roussy Institute, Villejuif, France.​


3. Development of new models of bone metastases from solid tumors (neuroblastomas, osteosarcomas) using mesenchymal stromal/stem cells and the establishment of humanized ossicles.

Project leaders: Francoise Pflumio (Research Director​, francoise.pflumio@cea.fr) and Julien Calvo (Chercheur, julien.calvo@cea.fr); Project members: C. Houques (Postdoc), L. Renou (Research Engineer), T. Taibi (PhD student)
In collaboration with I. Janoueix’s team, Institut Curie, Paris, and A. Marchais’s team, Gustave Roussy, Villejuif, France.


4. Studying the effects of a fusion involving the ABL1 gene on chemo-resistance in T/B-ALL.

Project leaders: Federica Ferri (Researcher, federica.ferri@cea.fr) and Laurent Renou (Research Engineer); Project members: R. Haddad (Professor, Paris-Saclay University)
In collaboration with H. de Thé’s team, Collège de France, Paris.​


5. Early leukemogenic events in B-ALL with ETV6-Runx1 fusion.

Project leader: Rima Haddad (Professor, Paris-Saclay University, rima.haddad@cea.fr). Project members: L. Renou (Research Engineer); F. Ferri (Researcher)

​
6. Evaluation of chemical compounds or mesenchymal stem cells for hematopoietic and gastrointestinal regeneration after acute irradiation.

Project leaders: Stéphanie Moreno (Researcher, CEA, stephanie.moreno@cea.fr) and Nathalie Gault (Researcher ; nathalie.gault@cea.fr); Project members: D. Lewandowski (Researcher), B. Bah (Technician)
Collaborations with IDMIT, ASNR, IRBA, EFS, and European teams.


7. Thymic regeneration in aged individuals using human progenitor cells.

Project leader: Francoise Pflumio (Research Director​, francoise.pflumio@cea.fr); Project members: J. Roche-Naude (PhD student)
​In collaboration with S. Soheili and O. Nègre, MEIRAGTx​.

​






Le projet "In Vivo" de la Fonda​tion ARC 



Articles available via Life Sciences, Université Paris-Saclay:

COLLABORATIONS

Thomas Mercher, Gustave Roussy Institute, Villejuif, FR.
Antonin Marchais, Gustave Roussy Institute, Villejuif, FR.
Isabelle Janoueix, Curie Institute, Paris, FR.
Raphael Rodriguez, Curie Institute, Paris, FR.
Michaela Fontenay et Olivier Kosmider, INSERM U1016, Cochin Institute, Paris, FR.
Ana Bigas, Jose Carreras Leukemia Research Institute, Barcelone, Spain.
Josef Vormoor, Princess Maxima Hospital, Utrecht, NL.
Shabi Soheili and Olivier Nègre, Company "MeiraGTx", New York, USA.
Arnaud Petit, Hôpital Trousseau, Paris, FR.
Jéléna Martinovic, Hôpital A Béclère, Clamart, FR​.


The team is a member of the board of the Hematology Federation of the University of Paris-Saclay  (https://federation-hematologie-upsaclay.com).

The team is a member of the La Leucémie-St Louis University Hospital Institute, Paris (https://www.institut-leucemie.fr) and of the Carnot OPALE Institute (https://www.opale.org/fr/).

The team participates in the CONECT-AML a​nd Paris Kids Cancer​ (https://presse.curie.fr/paris-kids-cancer-accelere-la-recherche-en-onco-hematologie-pediatrique-en-ile-de-france/?lang=fr) research networks.


​LABELS AND FUNDING

​​​​

 

 

​

​

Publications
Team​​ ​​
​Social Events

Top page