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The last two years in scientific news
Find here all the scientific news and highlights about the François Jacob Institute of Biology.
The term "synucleinopathy" covers a range of diseases, including Parkinson's disease, Lewy body dementia and multiple system atrophy, that involve pathological alpha-synuclein aggregations. An analysis of the properties of the different aggregate strains present in synucleinopathies has delineated the molecular bases of the diseases. The study, led by MIRCen (CEA-Jacob) researchers in partnership with the University of Louvain and Imperial College London, was published in Acta Neuropathologica
A year and a half after the publication of the complete sequence of the pedunculated oak genome by a national consortium led by INRAE and CEA (Genoscope), the first results based on this genomic resource are the subject of a series of articles published on 16 April 2020 in the journal New Phytologist.
Through an international collaboration, researchers from the LRTS laboratory (IRCM/CEA-Jacob) have characterized the cellular and molecular events regulating the balance between fibrotic repair and tissue regeneration and have identified a key player in this balance : macrophages. This study, published in Science Advances, opens up a new therapeutic perspective for the treatment of pathological tissue lesions.
As soon as the Government announced that the pandemic had reached stage 3 and that the national containment system would be implemented, CEA mobilized to maintain its essential functions, while helping to combat the spread of the virus and protect the health of its 20,000 employees.
A study led by IMVA-HB/IDMIT researchers, published in NPJ Vaccines, has shown the influence of the delay between vaccinations (primary and booster) on the specific humoral immune response. This work also suggests the establishment of a trained immune memory.
Researchers from the SEPIA (CEA)-Sup'Biotech partnership laboratory and the Gly-CRRET (UPEC) laboratory have developed a genetic tool for the long-term expression of proteins in human brain organoids. This work, published in Frontiers in Cellular Neuroscience, concerns the modelling of a genetic form of frontotemporal dementia, a neurodegenerative disease with a tauopathic side similar to Alzheimer's disease.
Scientists from the Laboratory of Neurodegenerative Diseases (MIRCen/ François Jacob Institute of Biology) in collaboration with the Neurocentre Magendie (Inserm/University of Bordeaux) have highlighted the decisive role played by a metabolic pathway in memory disorders in Alzheimer's disease. Their work, published in Cell Metabolism, also shows that L-serine intake, in the form of a dietary supplement, restores the spatial memory that is affected early on in mouse models of the disease.
As part of an international partnership, a team from the Neurodegenerative Diseases Laboratory (MIRCen) has characterized the pathological effects of various alpha-synuclein aggregate strains in vivo. In their work, published in Acta Neuropathologica Communications, the researchers showed that the conformation of these aggregates plays a key role in their amplification and propagation in the brain.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.