The François Jacob Institute of Biology brings together five departments and three services
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Bioinformatics analyses for genomics and metabolism
LABGeM is a bioinformatics group which addresses comparative genomic analysis and the metabolism of prokaryotic organisms. The main research fields addressed by LABGeM are
(meta)genomics (statistics applied to genomic data, dynamics and evolution of bacterial genomes, analysis of genes of unknown function) and
bacterial metabolism (prediction, curation and comparison of metabolic networks, investigation for 'orphan' candidate genes for enzymatic activities for sequencing).
With a view to conducting those analyses, a
platform for the annotation and comparative analysis of prokaryotic genomes has been set up:
the MicroScope platform. The IT infrastructure incorporates the data (genomes, automated and expert annotations, analytical results and experimental data) and Web graphic interfaces enabling exploration of the data and use of the methodological tools regularly incorporated in the platform. LABGeM thus also has considerable commitment to bioinformatics development for the
structural, functional and relational
annotation of genomes, analysis of NGS data on the applications of re-sequencing (variant detection) and analysis of transcriptomic data (RNA-Seq), design of
genomic and metabolic database models and the setup of WEB servers enabling access to the methods and databases.
In January 2012, the activities of the Department and Research & Development at LABGeM were
certified ISO 9001:2008. The MicroScope platform has been labeled IBiSA (Infrastructures in Biology, Health and Agronomics) and belongs to the major national infrastructures
France Génomique and the
Institut Français de Bioinformatique.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.