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Laboratory of Genetic Instability Research - LRIG

​ Laboratoire de Recherche sur l'Instabilité Génétique - LRIG
Published on 23 December 2025
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DNA repair and recombination:
a delicate balance between genomic fidelity and diversity
Maintaining the fidelity of genetic information is a critical function for all organisms. In higher eukaryotes, the accumulation of mutations can increase pathologies such as cancer or neurodegenerative diseases. On the other hand, evolution involves genetic changes.

In our laboratory, we are interested in understanding the fundamental basis of these two aspects by studying the mechanisms involved in the remarkable genetic diversity of the human pathogenic bacterium Helicobacter pylori.


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  ​Pablo RADICELLA
  Principal investigator
  ​Phone : +33 (0)1 46 54 88 57
  pablo.radicella@ce​a.fr


  Secretary :​
  Aurélie GOURET
  Phone : +33 (0)1 46 54 98 66

COLLABORATIONS

Jessica Andreani and Raphaël Guérois, I2BC, Gif sur Yvette, France
Calum Johnston and Patrice Polard, CNRS, Toulouse, France
Manuela Hospenthal, ETH Zurich, Switzerland
Ankur Dalia, University of Indiana, Bloomington, USA
Pedro Oliveira, GENOSCOPE, Evry, France​​


​ Research Projects
Publications​​​
​Team​