The François Jacob Institute of Biology brings together five departments and three services
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The expertise of MIRCen in the domain of PET imaging covers the following strategic axes:
1. The validation of radiotracers in validated animal models of human diseases.
2. The validation of animal models by PET with validated radiotracers.
The PET platform also works closely with the NMR and histology platforms for the three-dimensional reconstruction of multimodal images (Image Processing platform).
PET imaging system for rodents
The PET platform currently houses:
The radiochemistry platform allows the radiosynthesis and the development of new radiotracers specific to biological targets involved in a pathological process. Labeling concerns little molecules (molecular weight < 500 Da) and macromolecules (molecular weight > 500 Da) also. The future in house cyclotron will produce the 2 short half-life radioisotopes 11C and 18F (20.4 and 109.8 minutes respectively):
Since the opening of MIRCen, PET tracers have been radiolabeled at the Radiochemistry Laboratory of Frédéric Joliot Hospital, with a biomedical cyclotron and dedicated synthesizers housed in ventilated, shielded areas, according to current regulations. The future new radiochemistry infrastructure will make use of the same facilities.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.