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The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
Bringing successive mutations to DNA and RNA in test tubes has been possible for several decades now. A MIRCen team has shown that high throughput sequencing can, with unequaled precision, reconstitute the evolutionary path taken by these macromolecules during their in vitro selection process, and furthermore that this path respects Darwinian theory.
Three new species have joined the curious genus of viral giants called Pandoravirus. Both freak shows and innovators in evolution, the giant viruses continue to shake the phylogenetic tree!
The François Jacob Institute of Biology participated in a study showing that caloric restriction greatly increases longevity in a small primate called the mouse lemur.
The efficacy of a gene therapy developed at the François Jacob Institute of Biology and Harvard University has been demonstrated in phase I/II clinical trials.
Researchers at IRCM have shown that certain mechanisms involved in DNA repair are influenced by the intramolecular and intranuclear spatial organization of the macromolecule.
The results of a study performed by a research team at MIRCen suggest that the protein DCLK3 plays a key role in transcription regulation, and its deficit in Huntington's disease a key role in neurodegeneration.
Researchers from MIRCen have brought to light a reduction in the amount of an amyloid beta peptide associated with Alzheimer's disease in the plasma of a primate model during the summer season.
Neurofibrillary tangles are large aggregates of tau protein found in the neurons of people with Alzheimer's disease. Historically, they have been thought to be at least partially responsible for the pathology. However, the results of a study performed by researchers at MIRCen (François Jacob Institute of Biology/CEA) suggest to the contrary that neurofibrillary tangles may be protective.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.