The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
Find here all the scientific news and highlights about the François Jacob Institute of Biology.
Researchers from MIRCen (CEA-Jacob) have shown that undetectable proteinaceous aggregates involved in Alzheimer's disease can be transmitted during brain surgeries in an experimental context.
The nuclear power plant accidents at Chernobyl and Fukushima released enormous amounts of radioactive iodine into the atmosphere. Researchers from IRCM (CEA-Jacob) propose an analysis of data on the health consequences of those accidents and particularly the effects they had on the thyroid.
In a recent work published in Frontiers in Microbiology, a team from Genoscope (CEA-Jacob) has shown a role for corrinoids in the degradation of chlorine compounds (such as chlordecone or lindane) by the bacterium Citrobacter sp86. Because their increased production in contaminated environments could accelerate decontamination processes, these corrinoids may lay paths to novel bioremediation applications.
The LSHL (IRCM/CEA-Jacob) and the radiation oncology department of the Lausanne University Hospital teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Their results, published in the International Journal of Radiation Oncology * Biology * Physics, open new paths to treat this type of leukemia while preserving normal hematopoiesis.
Researchers from IRCM (CEA-Jacob) have identified a DNA sequence polymorphism that leads to reduced production of interferon β by myeloid cells. The substitution, which is present in about 30% of the population, could affect immune response to infections and tumors.
In an article published in Acta Neuropathologica, researchers from SEPIA (CEA-Jacob) reported the discovery of a new mode of prion propagation from a localized contamination.
Researchers from IDMIT (CEA-Jacob) and the Institut Pasteur teamed for a study in which they showed that the antiviral activity of CD8+ T lymphocytes remained limited in the first two weeks of infection but grew progressively and durably thereafter in macaques able to control simian immunodeficiency virus infection (the equivalent of HIV infection in non-human primates). Their results suggest that the early development of highly effective memory CD8+ T-cells is essential for achieving viral control.
In a study published in Cells, researchers from LGRK (IRCM/CEA-Jacob) showed that human skin stem cells are sensitive to low doses of genotoxic stress in the setting of active regeneration.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.