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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
A Reseach Team of the SB2SM, specialist in structural and predictive bioinformatics, collaborates with a Team from the Institute of Molecular Biology of Plants (Strasbourg) to study the mechanisms of the evolution of a metabolic pathway from a cytochrome P450 retroposition in Brassicaceae. This work shows how a gene duplication can favor the emergence of new metabolic functions, whose key residues of the active site can be identified by homology modeling.
An in vivo, in vitro and in silico study of the Mediator of Transcriptional Regulation has shown how the function of this multiprotein complex is coordinated with another essential component of the transcription machinery, the TFIIB factor, and the architecture of the promoter. This study, led by SBIGeM, was conducted in collaboration with several other Research Teams (CNRS, CEA, INRA).
This work, stemming from a collaboration between researchers from Imperial College London and an SB2SM Research Team, resolved a long-standing ambiguity about the redox potential (Em) value of the primary quinone, QA, of the Photosystem II (PSII). In addition, the authors discovered a new and very important phenomenon for the PSII: a reversible control effect of the redox potential of QA induced by binding of bicarbonate.
The research project M-CUBE, carried by the Aix Marseille University (AMU) via the Fresnel Institute and the Center for Magnetic Resonance Biological and Medical (CRMBM), was selected by the European Commission as part of the program Horizon 2020.
The group of Julien Flament is working on a new MRI modality, called CEST for Chemical Exchange Saturation Transfer, allowing in vivo mapping of some brain metabolites with a good spatial resolution. In the framework of a translational project funded by ANR (HDeNERGY project).
The psychiatry team of the clinical research UNIACT Lab at NeuroSpin, have published a study comparing with multimodal MRI two very frequent psychiatric conditions: high-functioning autism (also known as Asperger's syndrom) and schizophrenia.
The group of Marc Dhenain (MIRCen) has developed an MRI microscopy technique that can track in vivo the fate of amyloid plaques. This technique was used to characterize an immunotherapy targeting specific forms of amyloid (called protofibrillar). The article, published in collaboration with Sanofi, demonstrates an effective partnership between the CEA and industrial partners.
Recent work from the IMIV research lab suggests that tumor heterogeneity measured in vivo using PET images actually reflects the biological heterogeneity as measured ex vivo using pathological slides.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.