To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Laboratory | Structural biology | Radiobiology
Team LeaderJean-Baptiste CHARBONNIERTél : 01 69 08 76 77JB.CHARBONNIER@cea.fr
StaffJessica Andreani, ResearcherYves Boulard, ResearcherJean-Baptiste Charbonnier, Researcher Stéphane Bressanelli, ResearcherPhilippe Cuniasse, ResearcherPascal Drevet, ResearcherSonia Fieulaine, ResearcherBernard Gilquin, ResearcherRaphaël Guerois, ResearcherMarie-Helene Le Du, ResearcherMichel Masella, ResearcherSimona Miron, ResearcherG wenaëlle Moal-Raisin, TechnicianFrançoise Ochsenbein, ResearcherMaïté Paternostre, ResearcherLaure Plançon-Arnould, Univ. PSud LecturerCarine Tellier-Lebegue, Technician François-Xavier Theiller, ResearcherSophie Zinn-Justin , Researcher
The globular modules or domains have multiple functions including regulation of the enzymatic activities of proteins and orchestration of the cellular signaling. They are usually conserved during evolution, and we identify them using bioinformatics approaches. Their 3D structure is determined by NMR or X-ray crystallography. Their arrangement within the modular protein is observed by SAXS and NMR. Their interactions are characterized by NMR, biochemistry, fluorescence or calorimetry. Crystallography provides access to the structure of multi-functional protein complexes. Our structures are positionned in electron microscopy maps in order to build pseudo-atomic models of functionally important complexes.
Clearly, molecular modeling is a central tool in the laboratory that gives access to models consistent with heterogeneous structural data. On the experimental point of view, in addition to standard laboratory equipment, we have a comprehensive NMR park (500MHz, 600MHz, 700MHz), and we benefit from the proximity of the synchrotron SOLEIL which is in operation since 2006. The laboratory has an extensive expertise in the different techniques that give access to an atomic understanding of biological processes. Its location in an environment of cell biologists and geneticists favors synergies between in vitro and in vivo approaches.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.