To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
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Laboratory | Chemistry
Team Leader(to be nominated)
François ANDRÉ, ResearcherAnnie BARRAND-FRELET, ResearcherAlain DESBOIS, Researcher
Stéphane ORLOWSKI, ResearcherJérôme SANTOLINI, ResearcherMedhi LEMBROUK, Engineer assistant
Bosco JOSEPH, TechnicianMarine WEISSLOCKER--SCHAETZEL, Phd student
Reactive oxygen and nitrogen species are continuously produced in cells in order to carry out various physiological functions. The nature and flow of these species are fully controlled by biochemical adapted and adaptable systems. The imbalance between disposal systems and production of these species leads to dysfunction of macromolecules and cells at the heart of the phenomenon of oxidative stress. In humans, these dysfunctions are the cause of many diseases such as neurodegenerative diseases, some cancers as well as diseases produced by exposure to the environment. Detoxification is a set of processes which target biotransformation and / or transport of exogenous substances. In response to stress, activation of detoxification systems is linked to the action of antioxidant metabolism enzymes.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.