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Publié le 3 décembre 2021

​2020-present : 

Broad spectrum compounds targeting early stages of rabies virus (RABV) infection.

S Kali, C Jallet, S Azebi, T Cokelaer, JP Da Fonseca, Y Wu, J Barbier, JC Cintrat, D Gillet, N Tordo. Antiviral Res. 2021, 105016


Flexizyme-aminoacylated shortened tRNAs demonstrate that only the aminoacylated acceptor arms of the two tRNA substrates are required for cyclodipeptide synthase activity.

N Canu, C Tellier, M Babin, R Thai, I Ajel, J Seguin, O Cinquin, R Vinck, M Moutiez, P Belin, J-C Cintrat, M Gondry

Nucleic Acids Research, 2020, 48(20), 11615-11625


Structure-activity relationship studies of Retro-1 analogs against Shiga toxin.

H Abdelkafi, A Michau, V Pons et al.

J Med Chem 2020, 63, 15, 8114-8133


Shiga Toxin Uptake and Sequestration in Extracellular Vesicles Is Mediated by Its B-Subunit

A Willysson, A-L Ståhl, D Gillet, J Barbier, J-C Cintrat, V Chambon, A Billet, L Johannes, D Karpman

Toxins 2020, 12, 449


NMR Characterization of the Influence of Zinc(II) Ions on the Structural and Dynamic Behavior of the New Delhi Metallo-β-Lactamase-1 and on the Binding with Flavonols as Inhibitors

Riviere, G; Oueslati, S; Gayral, M; Crechet, J-B; Nhiri, N; Jacquet, E; Cintrat, J-C; Giraud, F; van Heijenoort, C; Lescop, E; et al

ACS Omega 2020, 5(18), 10466-10480


Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2

A. Forrester, S.J. Rathjen et al.

Nat Chem Biol 2020, 16, 327-336


Regulation of endo-lysosomal pathway and autophagic flux by broad-spectrum antipathogen inhibitor ABMA

Y. Wu, C. Boulogne, Claire; S. Carle et al.

FEBS J. 2020,


Revisiting Old Ionophore Lasalocid as a Novel Inhibitor of Multiple Toxins

N. Mahtal, Y. Wu, J.-C. Cintrat et al.

Toxins 2020, 12(1), 26


Photochemical Strain-Release-Driven Cyclobutylation of C(sp(3))-Centered Radicals

G. Ernouf, E. Chirkin, L. Rhyman, P. Ramasami, J.‐C. Cintrat

Angew Chem Int Ed Engl. 2020, 59(7), 2618-2622


Glucocorticoids delay RAF-induced senescence promoted by EGR1

C. Carvalho, V. L'Hôte, R. Courbeyrette, G. Kratassiouk, G. Pinna, J.-C. Cintrat, C. Denby-Wilkes, C. Derbois, R. Olaso, J.-F. Deleuze, C. Mann, J.-Y. Thuret

J. Cell Science, 2019, 132(16)   

2015-2019 : 

DABMA: A Derivative of ABMA with Improved Broad-Spectrum Inhibitory Activity of Toxins and Viruses

Y. Wu, V. Pons, Noel, Romain; et al.

ACS Med Chem Lett. 2019, 10(8), 1140-1147  


Spermine-NBD as fluorescent probe for studies of the polyamine transport system in Leishmania donovani

E. Jagu, S. Pomel, S. Pethe, J.-C. Cintrat, P.M. Loiseau, R. Labruere,

Bioorg Med Chem Lett. 2019, 29(14), 1710-1713:


Antiviral Effect of Retro-2.1 against Herpes Simplex Virus Type 2 In Vitro

W. Dai, Y.Wu, J. Bi, et al.

J. Microbiol Biotechnol. 2018, 28(6), 849-859


Screening of a Drug Library Identifies Inhibitors of Cell Intoxication by CNF1

N. Mahtal, C. Brewee; S. Pichard; et al.

ChemMedChem 2018, 13(7), 754-761


Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo

W. Dai, Y. Wu, Bi, Jinpeng; et al.

Viruses, 2018, 10(3), E119


Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection

O. Shtanko, Y. Sakurai, A.N. Reyes, et al.

Antiviral Res., 2018, 149, 154-163


ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments.

Y. Wu, V. Pons, A. Goudet, L. Panigai, A. Fischer, J. Herweg, S. Kali, R. Davey, J. Laporte, C. Bouclier, R. Yousfi, C. Aubenque, G. Merer, E. Gobbo, R. Lopez, C. Gillet, S. Cojean, M.R. Popoff, P. Clayette, R. Le Grand, C. Boulogne, N. Tordo, E. Lemichez, P.M. Loiseau, T. Rudel, D. Sauvaire, J.C. Cintrat, D. Gillet, J. Barbier.

Sci Rep, 2017, 7(1), 15567


Antiviral effects of Retro-2cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo

W. Dai, Y. Wu, J. Bi, X. Lu, A. Hou, Y. Zhou, B. Sun, W. Kong, J. Barbier, JC Cintrat , F. Gao, D. Gillet, W. Su W, C. Jiang

Antiviral Res., 2017, 144, 311-321


Vaccinia Virus Uses Retromer-Independent Cellular Retrograde Transport Pathways To Facilitate the Wrapping of Intracellular Mature Virions during Virus Morphogenesis

K. Harrison, I.R. Haga, T.P. Jowers, et al.

J. Virol., 2016, 90(22), 10120-10132


Retro-1 Analogues Differentially Affect Oligonucleotide Delivery and Toxin Trafficking

B. Yang, X. Ming, H. Abdelkafi, et al.

ChemMedChem, 2016, 11(22), 2506-2510


Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales  

N. Gupta, R. Noel, A. Goudet, K. Hinsinger, A. Michau, V. Pons, H. Abdelkafi, T. Secher, A. Shima, O. Shtanko,  et al

Chemico-Biological Interactions 2016,


Palladium-catalyzed chemoselective and biocompatible functionalization of cysteine-containing molecules at room temperature

RAA Al-Shuaeeb, S. Kolodych, O. Koniev, et al.

Chem Eur J 2016, 22(32), 11365-11370  


Intracellular pathogens convert macrophages from death traps into hospitable homes

J. Barbier, J.-C. Cintrat, D. Gillet

FEBS Journal 2016, 283(4), 595-597


Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation

H. Abdelkafi, J.-C. Cintrat

Scientific Reports 2015, 5, 12131


Retrograde trafficking inhibitor of Shiga toxins reduces morbidity and mortality of mice infected with enterohemorrhagic Escherichia coli.

T. Secher, A. Shima, K. Hinsinger, J.-C. Cintrat, L. Johannes, J. Barbier, D. Gillet, E. Oswald.

Antimicrob Agents Chemother 2015, 59, 5010-5013


Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin.

Garcia-Castillo MD, Tran T, Bobard A, Renard HF, Rathjen SJ, Dransart E, Stechmann B, Lamaze C, Lord M, Cintrat JC, Enninga J, Tartour E, Johannes L.

J Cell Sci. 2015; 128(13), 2373-2387


Synthesis, Chiral Separation, Absolute Configuration Assignment, and Biological Activity of Enantiomers of Retro-1 as Potent Inhibitors of Shiga Toxin

H. Abdelkafi, A. Michau, A. Clerget, D.-A. Buisson, L. Johannes, D. Gillet, J. Barbier, J.-C. Cintrat

ChemMedChem, 2015, 10(7), 1153-1156


Syntaxin 5-Dependent Retrograde Transport to the Golgi is Required for AAV Transduction M. Nonnenmacher, J.-C. Cintrat, D. Gillet, T. Weber

J. Virol., 2015, 89(3), 1673-1687


Les contre-mesures thérapeutiques progressent au pas de charge

J.-C. Cintrat, J. Barbier, C. Lombardi, V. Job, I. Attree, A. Dessen, L. Bellanger, S. Simon

Biofutur, 2015, 363, 46-49


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