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The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
Researchers from LABGeM (CEA-Jacob), LaMME and the Pasteur Institute joined forces to develop a novel method for the analysis of prokaryote pangenomes, called PPanGGoLiN. As a complement to PPanGGoLiN, the team developed a second tool, panRGB, which brought unprecedented performance and speed to massive comparative genomics analyses.
A study co-piloted by researchers from LGRK (IRCM/CEA-Jacob) and Claude Bernard Lyon 1 University and performed on cells from patients who experienced severe adverse effects after radiation therapy enabled the identification of a novel molecular signature of excessive radiosensitivity in healthy tissues.
The CNRGH contributed to a work showing that tobacco exposure, even when stopped before becoming pregnant, leaves traces in the placenta in the form of epigenetic modifications to its DNA.
Researchers from MIRCen (CEA-Jacob) teamed with the Frédéric Joliot Medical Imaging Center (SHFJ; CEA-Joliot) and the Henri-Mondor and Saint-Anne Hospitals to analyze neuroinflammatory response in a cohort of patients with Parkinson's disease and reported a correlation between it and disease progression. Their study, published in Parkinsonism & Related Disorders, sets a path toward the use of a radiotracer, [¹⁸F]-DPA714, for the evaluation of anti-inflammatories pertinent to the treatment of Parkinson's disease.
In an article published in NeuroImage, a CEA/CNRS/Paris-Saclay University team from MIRCen (CEA-Jacob) has described neuronal networks in the mouse lemur (Microcebus murinus), one of the smallest primates and one of the most genetically-distant from humans.
Researchers from MIRCen (CEA-Jacob) have shown that undetectable proteinaceous aggregates involved in Alzheimer's disease can be transmitted during brain surgeries in an experimental context.
The nuclear power plant accidents at Chernobyl and Fukushima released enormous amounts of radioactive iodine into the atmosphere. Researchers from IRCM (CEA-Jacob) propose an analysis of data on the health consequences of those accidents and particularly the effects they had on the thyroid.
In a recent work published in Frontiers in Microbiology, a team from Genoscope (CEA-Jacob) has shown a role for corrinoids in the degradation of chlorine compounds (such as chlordecone or lindane) by the bacterium Citrobacter sp86. Because their increased production in contaminated environments could accelerate decontamination processes, these corrinoids may lay paths to novel bioremediation applications.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.