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The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
In a new study published in Brain, researchers MIRCen used mouse models of Huntington's disease to show that stimulating reactive astrocyte formation favors the elimination of mutant huntingtin protein, reducing both the quantity and size of the aggregates.
The Epigenetic and Environment Laboratory (CNRGH) was part of a study that characterized associations between placental DNA methylation and the concentrations of 11 phthalate-derived metabolites in urine samples from pregnant women. The samples used for the analysis, published in Environment International, were obtained from EDEN, a cohort of French mothers and children.
As part of a international partnership, researchers from SRHI have shown that Crispr/Cas9 can be used to inactivate HLA-G expression in human cancer cell lines. Their unprecedented findings, published in Scientific Reports, suggest the possibility of novel treatment strategies to supplement current tumor immunotherapies.
Preclinical trials carried out as part of a CEA-Irig–CEA-Jacob partnership have shown that a spike-protein-based candidate vaccine provides complete protection against SARS-CoV-2 infection.
Researchers from IRCM furnish initial information on the mechanisms regulating DNA double-strand break repair in yeast heterochromatin. Sir3 plays an essential role in the choice of a repair pathway.
An international team with researchers from the CEA (Genoscope, CEA-Jacob) has produced a dataset of the deep ocean floor and compared it to the other oceanic realms at a worldwide scale. The results, published in the in Science Advances, show that the deep oceanic floor is home to a mostly unknown biodiversity largely superior to that of plankton.
In a study published in Viruses, a team of researchers from SRHI and the University of Ferrara (Italy) showed that the soluble form of HLA-G may contribute significant anti-inflammatory properties via its role in controlling the adhesion of neutrophils to endothelial cells and thus improve disease outcome in patients with COVID-19.
In a study published in Cancer Letters, SRHI's researchers (CEA-Jacob) highlight the therapeutic value of targeting the HLA-G/IL2 immune checkpoint in clear cell renal cell carcinoma.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.