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The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
In an article published in Science of The Total Environment, researchers from the Genomics Metabolics mixed research unit (Genoscope/CEA-Jacob) teamed with colleagues from the University of Lorraine to demonstrate the role of thermophilic anaerobic digestion in the biodegradation of chlordecone.
In a new study published in Nature Communications, researchers from IDMIT and the QIMR Berghofer Institute have shown that a peptide able to inhibit the nuclear ACE2 receptor provides protection against SARS-CoV-2 infection.
In a study published in Heliyon, researchers from IDMIT (CEA-Jacob) used a well-characterized non-human primate model to show that sotrovimab is efficacious against the BQ.1.1 subvariant of SARS-CoV-2. Their results lend support for the continued use of sotrovimab in patients ineligible for nirmatrelvir/ritonavir.
In a new study performed in a mouse model and published in Acta Neuropathologica Communications, researchers from the LMN (MIRCen/CEA-Jacob) have shown that the experimental transmission of abnormal amyloid-β proteins accelerates, over time, the development of cerebral lesions and memory disorders.
In an article published in Neurobiology of Disease, researchers from MIRCen's Neurodegenerative Diseases Laboratory present a novel model of Alzheimer's disease that enables the study of tauopathy inter-neuronal propagation mechanisms, the identification of new therapeutic targets and the exploration of new treatments.
In a work published in Cell Reports, researchers from the SGCSR mixed research unit (IRCM) have shown that the loss of XLF (a.k.a. Cernunnos), a component of the non-homologous end-joining complex, severely alters brain development and function in mice.
Using samples collected during the Tara Oceans expeditions and sequencing "big data" generated by Genoscope, an international research team has discovered an important group of DNA viruses living among ocean surface plankton. Published in Nature, this discovery brings novel opportunities for the field of ecology and the elucidation of DNA virus evolution pathways, in the seas and beyond.
Seeking to contribute to greener chemistry and via the exploration of biodiversity, the biocatalysis team at L2BMS (UMR8030/Genoscope) has identified amine-synthesizing enzymes and shed light on the key catalytic characteristics of a number of them. Their work was recently published in Frontiers in Catalysis.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.