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The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
Researchers at IRCM have developed and characterized in vivo humanized bone marrow models. These results open up new perspectives for research on leukemia, on protective interactions between cancer cells and bone marrow cells, and may help to pave the way for personalized therapies.
Researchers from IDMIT Department has developed a PET imaging strategy to visualize and quantify the distribution of SARS-CoV-2 throughout the whole body in a non-human primate model. These findings were published in Nature Communications.
Researchers from Mircen contributed to a study published in Brain, showing in a mouse model the role of a gene, DLCK3, in modulating anxiety and memory.
In a study published in Nucleic Acids Research (NAR), researchers from IRCM reveal fine-tuned mechanisms regulating the transition of germ cells from mitosis to meiosis during mouse spermatogenesis, providing new insights into certain forms of male infertility.
An international consortium, including laboratories from CNRS and Genoscope, has sequenced the giant X and Y chromosomes of the plant Silene latifolia. This work, published in Science, sheds light on sex determination in plants.
In a study published in Nature Communications, IDMIT researchers demonstrated the efficacy of a neutralizing antibody against cell-associated infection by simian-human immunodeficiency virus.
Using a murine preclinical model wherein Rad51 was selectively inhibited, researchers from the Laboratory of Development of the Gonads (iRCM:CEA-Jacob) and the Institut Cochin showed that in vivo alteration of Rad51-mediated homologous recombination does not favor the development of cancers, it reduces it. The team's work was published in The Embo Journal.
In an article published in Nature Communications, researchers from Institut Jacques-Monod and iRCM (CEA-Jacob) merged imaging and biochemistry approaches to show that the genes involved in expression are conducted to nuclear pores in order to protect the genome.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.