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The CNRGH laboratories
Team leader: Jean-François Deleuze E-mail: deleuzecnrgh.fr
The Development Laboratory (LD) of the CNRGH has two major objectives: data production and technological development.
The Development Laboratory implements DNA and RNA sequencing projects and expression projects (microarray and real-time PCR) for which the number of samples is limited (from a few units to a few hundred units). The projects requiring processing of a large number of samples are assumed by the Production Laboratory.
For targeted sequencing, the Laboratory is equipped with a set of automated technical solutions (Agilent system, Perkin Elmer system, TAP), sequencers (NextSeq500, MiSeq, Proton, PGM, 454) and other instruments (iScan, MxPro, nanodrop, bioanalyzer, etc.).
The Laboratory makes use of the expertise of the DNA/RNA Bank Laboratory of the CNRGH for the extraction, quality control and storage of biological specimens.
The data generated are analyzed in-house in cooperation with the Bioinformatics Laboratory and Quality Control team of the CNRGH.
The Laboratory is also responsible for testing new DNA and RNA analysis methods and conducts active technological monitoring in liaison with the various players in the sequencing field.
New sequencing approaches, new sequencers and new solutions for WES and targeted capture are tested, as are new protocols oriented toward small quantities and optimizations for degraded starting materials, DNA or RNA.
The LD works on projects in cooperation with French, European and international partners in various fields: neurodegeneration, cancer, rare diseases, inflammatory diseases, various human diseases, murine models of human diseases, etc.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.