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Dicentric chromosomes are abnormal structures that can be important contributors to pathological states. They are products of erroneous DNA repair events (e.g. accidental telomere fusions). During mitosis, they form anaphase bridges, resulting in chromosome breakage by an unknown mechanism. The general aim of the lab is to dissect the pathways preventing dicentrics formation and decipher how dicentric are broken upon mitotic exit and cytokinesis.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.