The François Jacob Institute of Biology brings together five departments and three services
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Our laboratory identified two transcriptomic signatures discriminating sporadic and radiation-induced thyroid tumors. These signatures are robust enough to predict the etiology of thyroid tumors (New and larger independent series of tumors being currently analyzed to confirm this result). Moreover, these first studies highly suggested that post-radiotherapy (thyroid dose of 20-40Gy) and post-Chernobyl tumors (thyroid dose of a magnitude of a few dozen mGy to a few Gy) display a common core of molecular specificity, which is independent of the mode of exposure (external exposure, Iodine131 contamination, respectively) and the dose, especially, five genes were found in both signatures.
This research has applications in the treatment of certain cancers and radiation protection. We interact with the nuclear industry (EDF and AREVA).
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.