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Laboratory Repair And Aging - LREV

Published on 19 December 2022

Our team is interested by understanding the mechanisms of genome maintenance and particularly, to characterize the relationships existing between senescence, oxidative stress control and DNA repair. Recent data highlight the importance of nuclear architecture on genome maintenance.

Our major projects aim to investigate the roles of nuclear envelope proteins in:
  1. DSB repair, 
  2. chromosome stability and telomeres metabolism, 
  3. redox control and 
  4. senescence mechanisms 

Bertrand P.png


Principal investigator
Phone : + 33 (0)1 46 54 88 46


Aurélie GOURET
Phone : +33 (0)1 46 54 98 66

​Major publications
Grabarz A, Guirouilh-Barbat J, Barascu A, Pennarun G, Genet D, Rass E, Germann S, Bertrand P, Hickson I.D and Lopez B.S.  Cell report, 5 :1-8, 2013

Aurelia Barascu, Catherine Le Chalony, Gaelle Pennarun, Diane Genet, Nancy Zaarour and Pascale  Bertrand. Nucleus, 1;3(5),411-417, 2012.

Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation.
Aurelia Barascu, Catherine Le Chalony, Gaelle Pennarun, Diane Genet, Naima Imam, Bernard S. Lopez and Pascale BertrandEMBO J, 31:1080-94, 2012,
Emilie Rass, Anastazja Grabarz, Isabelle Plo, Jean Gautier, Pascale Bertrand * & Bernard S Lopez*. (*corresponding authors). 
Nature Structural & Molecular Biology 16, 819 – 824, 2009,
Josée Guirouilh-Barbat* Emilie Rass* Isabelle Plo, Pascale Bertrand* and Bernard.S Lopez*. (*corresponding authors) 
Proc. Natl. Acad. Sci. USA, 104:20902-20905-1733, 2007.