The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
In a study published in Cancer Letters, SRHI's researchers (CEA-Jacob) highlight the therapeutic value of targeting the HLA-G/IL2 immune checkpoint in clear cell renal cell carcinoma.
In a study published in Science of the Total Environment, researchers from SIMoS (DMTS/CEA-Joliot), in collaboration with the Faculty of Pharmacy of Paris and MIRCen (CEA-Jacob) have shown for the first time in an animal model the capacity of Pinnatoxin-G, a marine neurotoxin, to cross physiological barriers to reach its molecular targets.
In a review published in Cell Metabolism, Gilles Bonvento (LMN/MIRCen/CEA-Jacob) and Juan P. Bolaños (IBFG/University of Salamanca) present the latest findings on astrocyte-neuron metabolic cooperation and how it affects brain function.
Dans le cadre d'une collaboration internationale, les chercheurs du Genoscope mettent en lumière de nouveaux organismes diazotrophes grâce aux données moléculaires et d'imagerie collectées par la goélette scientifique Tara entre 2009 et 2013.
A team of researchers from Inrae, Orleans University, the University of Oregon (USA), CEA-Jacob and IRD studied the role of epigenetics in drought tolerance in poplars. Their results, published in New Phytologist, suggest that epigenetic changes during droughts affect the genes involved in the tree's hormonal response to water deficits and may result in genetic mutations.
A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress.
In a study published in Cell Systems, the SysFate laboratory (UMR8030/Genoscope/CEA-Jacob) presented MULTILAYER, an algorithm that provides digital functional maps of biological organs or tissues.
The mechanisms that control the stability of telomeres, structures located at the ends of chromosomes, remain largely mysterious. One of them however has been decrypted by researchers from IRCM (CEA-Jacob) and I2BC (CEA-Joliot) in a work carried out in yeasts. Their results, published in Nature Communications, could help identify new therapeutic targets in human cancers.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.